Synthesis of 3-alkoxycarbonyl-1β-methylcarbapenem using palladium-catalyzed amidation of vinyl halide

被引：50

作者：

Kozawa, Y ^{[1
]}

Mori, M ^{[1
]}

机构：

[1] Hokkaido Univ, Grad Sch Pharmaceut Sci, Sapporo, Hokkaido 0600812, Japan

来源：

TETRAHEDRON LETTERS | 2002年 / 43卷 / 01期

关键词：

beta-lactam carbapenem; 3-alkoxycarbonyl-1; beta-methylcarbapenem; palladium-catalyzed amidation; palladium-catalyzed cyclization;

D O I：

10.1016/S0040-4039(01)02091-3

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

3-Alkoxycarbonyl-1 beta -methylcarbapenem could be synthesized using a palladium-catalyzed C-N bond-forming reaction. In this reaction, the use of Pd(OAc)(2) and DPEphos gave a good result, and generation of Pd(0) in the absence of a base is necessary to increase the yield. (C) 2001 Elsevier Science Ltd. All rights reserved.

引用

页码：111 / 114

页数：4

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