Autophagy: Supporting cellular and organismal homeostasis by self-eating

被引：86

作者：

Eskelinen, Eeva-Liisa ^{[1
,2
]}

机构：

[1] Univ Turku, Inst Biomed, Kiinamyllynkatu 10, FIN-20520 Turku, Finland

[2] Univ Helsinki, Mol & Integrat Biosci Res Programme, Helsinki, Finland

来源：

INTERNATIONAL JOURNAL OF BIOCHEMISTRY & CELL BIOLOGY | 2019年 / 111卷

基金：

芬兰科学院;

关键词：

Autophagy; Aging; Stem cells; Immunity; Inflammation; Neurodegeneration; Cancer; ALPHA-SYNUCLEIN; CROHNS-DISEASE; CELLS; INHIBITION; POLYGLUTAMINE; METABOLISM; MECHANISM; LYSOSOME; PATHWAYS; GENES;

D O I：

10.1016/j.biocel.2019.03.010

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

070307 [化学生物学]; 071010 [生物化学与分子生物学];

摘要：

Autophagy is a conserved catabolic process that delivers cytoplasmic components and organelles to lysosomes for degradation and recycling. This pathway serves to degrade nonfunctional organelles and aggregate-prone proteins, as well as to produce substrates for energy production and biosynthesis. Autophagy is especially important for the maintenance of stem cells, and for the survival and homeostasis of post-mitotic cells like neurons. Functional autophagy promotes longevity in several model organisms. Autophagy regulates immunity and inflammation at several levels and has both anti- and pro-tumorigenic roles in cancer. This review provides a concise overview of autophagy and its importance in cellular and organismal homeostasis, with emphasis on aging, stem cells, neuronal cells, immunity, inflammation, and cancer.

引用

页码：1 / 10

页数：10

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