Lanthanides - the future drugs?

被引：140

作者：

Wang, K ^{[1
]}

Li, RC ^{[1
]}

Cheng, Y ^{[1
]}

Zhu, B ^{[1
]}

机构：

[1] Beijing Med Univ, Dept Bioinorgan & Inorgan Pharmaceut Chem, Beijing 100083, Peoples R China

来源：

COORDINATION CHEMISTRY REVIEWS | 1999年 / 190卷

关键词：

lanthanides; drugs; pharmacological actions;

D O I：

10.1016/S0010-8545(99)00072-7

中图分类号：

O61 [无机化学];

学科分类号：

070301 ; 081704 ;

摘要：

Previous studies on the therapeutical application of lanthanides are critically reviewed. The difference in toxicity/activity between Ln and heavy metals is discussed on the basis of their similarity to calcium ion and deviation from it. Experimental results are summarized to show that the appropriate uses of the regulatory effects of Ln would be useful in therapeutical application. The perforation of cell membrane and apoptosis induced by Ln as well as their influence on ROS mediated oxidative damages and on the assembly and stability of cytoskeleton are discussed as the potential pharmacological action. A perspective of the integrated application of related bioactivities is shown in relation to their uses in anticancer treatment. (C) 1999 Elsevier Science S.A. All rights reserved.

引用

页码：297 / 308

页数：12

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