MicroRNAs in Metabolic Disease

被引：219

作者：

Fernandez-Hernando, Carlos

Ramirez, Cristina M.

Goedeke, Leigh

Suarez, Yajaira

机构：

[1] NYU, Sch Med, Dept Med, Leon H Charney Div Cardiol, New York, NY USA

[2] NYU, Sch Med, Dept Cell Biol, Leon H Charney Div Cardiol, New York, NY 10016 USA

[3] NYU, Sch Med, Marc & Ruti Bell Vasc Biol & Dis Program, New York, NY USA

来源：

ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY | 2013年 / 33卷 / 02期

关键词：

miRNAs; metabolic disease; lipoprotein metabolism; BETA-CELL; INSULIN-SECRETION; IN-VIVO; ADIPOCYTE DIFFERENTIATION; CHOLESTEROL HOMEOSTASIS; GLUCOSE-HOMEOSTASIS; NONHUMAN-PRIMATES; ALZHEIMER-DISEASE; GENE-EXPRESSION; PLASMA MICRORNA;

D O I：

10.1161/ATVBAHA.112.300144

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

Alterations in the metabolic control of lipid and glucose homeostasis predispose an individual to develop cardiometabolic diseases, such as type 2-diabetes mellitus and atherosclerosis. Work over the last years has suggested that microRNAs (miRNAs) play an important role in regulating these physiological processes. The contribution of miRNAs in regulating metabolism is exemplified by miR-33, an intronic miRNA encoded in the Srebp genes. miR-33 controls cellular cholesterol export and fatty acid degradation, whereas its host genes stimulate cholesterol and fatty acid synthesis. Other miRNAs, such as miR-122, also play a critical role in regulating lipid homeostasis by controlling cholesterol synthesis and lipoprotein secretion in the liver. This review article summarizes the recent findings in the field, highlighting the contribution of miRNAs in regulating lipid and glucose metabolism. We will also discuss how the modulation of specific miRNAs may be a promising strategy to treat metabolic diseases. (Arterioscler Thromb Vasc Biol. 2013;33:178-185.)

引用

收藏

页码：178 / 185

页数：8

相关论文

共 67 条

[1] miR-33 controls the expression of biliary transporters, and mediates statin- and diet-induced hepatotoxicity [J].

Allen, Ryan M. ;

Marquart, Tyler J. ;

Albert, Carolyn J. ;

Suchy, Frederick J. ;

Wang, David Q. -H. ;

Ananthanarayanan, Meenakshisundaram ;

Ford, David A. ;

Baldan, Angel .

EMBO MOLECULAR MEDICINE, 2012, 4 (09) :882-895

[2] MicroRNA pathways in flies and worms: Growth, death, fat, stress, and timing [J].

Ambros, V .

CELL, 2003, 113 (06) :673-676

[3] The functions of animal microRNAs [J].

Ambros, V .

NATURE, 2004, 431 (7006) :350-355

[4] Argonaute2 complexes carry a population of circulating microRNAs independent of vesicles in human plasma [J].

Arroyo, Jason D. ;

Chevillet, John R. ;

Kroh, Evan M. ;

Ruf, Ingrid K. ;

Pritchard, Colin C. ;

Gibson, Donald F. ;

Mitchell, Patrick S. ;

Bennett, Christopher F. ;

Pogosova-Agadjanyan, Era L. ;

Stirewalt, Derek L. ;

Tait, Jonathan F. ;

Tewari, Muneesh .

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 2011, 108 (12) :5003-5008

[5] Diabetes Mellitus and the β Cell: The Last Ten Years [J].

Ashcroft, Frances M. ;

Rorsman, Patrik .

CELL, 2012, 148 (06) :1160-1171

[6] MicroRNAs: Target Recognition and Regulatory Functions [J].

Bartel, David P. .

CELL, 2009, 136 (02) :215-233

[7] β-cell ABCA1 influences insulin secretion, glucose homeostasis and response to thiazolidinedione treatment [J].

Brunham, Liam R. ;

Kruit, Janine K. ;

Pape, Terry D. ;

Timmins, Jenelle M. ;

Reuwer, Anne Q. ;

Vasanji, Zainisha ;

Marsh, Brad J. ;

Rodrigues, Brian ;

Johnson, James D. ;

Parks, John S. ;

Verchere, C. Bruce ;

Hayden, Michael R. .

NATURE MEDICINE, 2007, 13 (03) :340-347

[8] Circulating MicroRNAs in Patients with Chronic Hepatitis C and Non-Alcoholic Fatty Liver Disease [J].

Cermelli, Silvia ;

Ruggieri, Anna ;

Marrero, Jorge A. ;

Ioannou, George N. ;

Beretta, Laura .

PLOS ONE, 2011, 6 (08)

[9] Nonalcoholic Steatohepatitis Is Associated with Altered Hepatic MicroRNA Expression [J].

Cheung, Onpan ;

Puri, Puneet ;

Eicken, Christoph ;

Contos, Melissa J. ;

Mirshahi, Faridoddin ;

Maher, James W. ;

Kellum, John M. ;

Min, Haeki ;

Luketic, Velimir A. ;

Sanyal, Arun J. .

HEPATOLOGY, 2008, 48 (06) :1810-1820

[10] miR-33a/b contribute to the regulation of fatty acid metabolism and insulin signaling [J].

Davalos, Alberto ;

Goedeke, Leigh ;

Smibert, Peter ;

Ramirez, Cristina M. ;

Warrier, Nikhil P. ;

Andreo, Ursula ;

Cirera-Salinas, Daniel ;

Rayner, Katey ;

Suresh, Uthra ;

Pastor-Pareja, Jose Carlos ;

Esplugues, Enric ;

Fisher, Edward A. ;

Penalva, Luiz O. F. ;

Moore, Kathryn J. ;

Suarez, Yajaira ;

Lai, Eric C. ;

Fernandez-Hernando, Carlos .

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 2011, 108 (22) :9232-9237

← 1 2 3 4 5 6 7 →