Mesenchymal Stromal Cells: Sensors and Switchers of Inflammation

被引：1101

作者：

Bernardo, Maria Ester ^{[1
]}

Fibbe, Willem E. ^{[2
]}

机构：

[1] IRCCS Bambino Gesu Children Hosp, Dept Pediat Hematol & Oncol, I-00165 Rome, Italy

[2] Leiden Univ, Med Ctr, Dept Immunohematol & Blood Transfus, NL-2333 ZA Leiden, Netherlands

来源：

CELL STEM CELL | 2013年 / 13卷 / 04期

关键词：

VERSUS-HOST-DISEASE; TOLL-LIKE RECEPTORS; SUPPRESS T-LYMPHOCYTE; STEM-CELLS; BONE-MARROW; IN-VITRO; MSCS; MICE; MACROPHAGES; RECRUITMENT;

D O I：

10.1016/j.stem.2013.09.006

中图分类号：

Q813 [细胞工程];

学科分类号：

摘要：

In addition to their stem/progenitor properties, mesenchymal stromal cells (MSCs) possess broad immunoregulatory properties that are being investigated for potential clinical application in treating immune-based disorders. An informed view of the scope of this clinical potential will require a clear understanding of the dynamic interplay between MSCs and the innate and adaptive immune systems. In this Review, we outline current insights into the ways in which MSCs sense and control inflammation, highlighting the central role of macrophage polarization. We also draw attention to functional differences seen between vivo and in vitro contexts and between species. Finally, we discuss progress toward clinical application of MSCs, focusing on GvHD as a case study.

引用

页码：392 / 402

页数：11

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