Recent advances in Tourette syndrome research

被引:356
作者
Albin, RL
Mink, JW
机构
[1] Univ Rochester, Sch Med & Dent, Dept Neurol, Rochester, NY 14642 USA
[2] Univ Rochester, Sch Med & Dent, Dept Neurobiol & Anat, Rochester, NY 14642 USA
[3] Univ Rochester, Sch Med & Dent, Dept Pediat, Rochester, NY 14642 USA
[4] Univ Michigan, Dept Neurol, Geriatr Res Educ & Clin Ctr, Ann Arbor VAMC, Ann Arbor, MI 48109 USA
关键词
D O I
10.1016/j.tins.2006.01.001
中图分类号
Q189 [神经科学];
学科分类号
071006 ;
摘要
Tourette syndrome (TS) is a developmentally regulated neurobehavioral disorder characterized by involuntary, stereotyped, repetitive movements. Recent anatomical and neuroimaging studies have provided evidence for abnormal basal ganglia and dopaminergic function in TS. Basic research on striatal inhibitory mechanisms and dopaminergic function complements the recent neuroimaging and anatomical data. Parallel studies of basal ganglia participation in the normal performance and learning of stereotyped repetitive behaviors or habits has provided additional insight. These lines of research have provided new pieces to the TS puzzle, and their increasing convergence is showing how those pieces can be put together.
引用
收藏
页码:175 / 182
页数:8
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