MicroRNA maturation and action - the expanding roles of ARGONAUTEs

被引：85

作者：

Mallory, Allison C. ^{[1
]}

Elmayan, Taline ^{[1
]}

Vaucheret, Herve ^{[1
]}

机构：

[1] INRA, Inst Jean Pierre Bourgin, Biol Cellulaire Lab, F-78026 Versailles, France

来源：

CURRENT OPINION IN PLANT BIOLOGY | 2008年 / 11卷 / 05期

关键词：

D O I：

10.1016/j.pbi.2008.06.008

中图分类号：

Q94 [植物学];

学科分类号：

071001 ;

摘要：

MicroRNAs are endogenously produced 21-nt riboregulators that associate with ARGONAUTE (AGO) proteins to direct mRNA cleavage or repress translation of complementary RNAs. In addition to protein-coding gene repression, miRNA-directed regulation of non-protein-coding transcripts can incite production of trans-acting siRNA (tasiRNA) populations that themselves direct mRNA repression. Arabidopsis encodes 10 AGO proteins among which, AGO1, AGO7, and AGO10 have been implicated in miRNA-guided gene repression in vivo. Recent work has shown that AGO proteins discriminate their associated small RNA populations on the basis of size and 5-terminal nucleotide identity, extending the roles of AGO proteins beyond small RNA action. Our expanding appreciation of miRNA-directed regulation during plant development and stress adaptations has placed miRNAs at the forefront of plant biology.

引用

页码：560 / 566

页数：7

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