How LFA-1 binds to different ligands

被引：46

作者：

Binnerts, ME ^{[1
]}

van Kooyk, Y ^{[1
]}

机构：

[1] Univ Nijmegen, Dept Tumor Immunol, Nijmegen, Netherlands

来源：

IMMUNOLOGY TODAY | 1999年 / 20卷 / 05期

关键词：

D O I：

10.1016/S0167-5699(99)01467-X

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

The integrin leukocyte function-associate antigen 1 (LFA-1) is pivotal for cell adhesion and signalling within the immune system. Here, Minke Binnerts and Yvette van Kooyk discuss evidence from mutational and crystallographic studies showing that binding of LFA-1 to its ligands intercellular adhesion molecule 1 (ICAM-1), -2 and -3 might be structurally distinct.

引用

页码：240 / 245

页数：6

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