Toward a New Toxicology - Evolution or Revolution?

被引：34

作者：

Hartung, Thomas ^{[1
,2
]}

机构：

[1] European Commiss Joint Res Ctr, Inst Protect & Secur Citizen, Traceabil Risk & Vulnerabil Assessment Unit, I-21027 Ispra, VA, Italy

[2] Univ Konstanz, Constance, Germany

来源：

ATLA-ALTERNATIVES TO LABORATORY ANIMALS | 2008年 / 36卷 / 06期

关键词：

alternatives; animal testing; new approaches and technologies; philosophy; risk assessment; safety assessment; toxicology;

D O I：

10.1177/026119290803600607

中图分类号：

R-3 [医学研究方法]; R3 [基础医学];

学科分类号：

1001 ;

摘要：

This essay summarises the author's thoughts on the current paradigm change in toxicology. The driving factors and mechanisms of this change, and obstacles to it, are discussed. Current developments are discussed on the basis of some key assumptions in Thomas Kuhn's famous book, The Structure of Scientific Revolutions. The author's personal view is that there is clear evidence that revolutionary changes in regulatory toxicology are emerging.

引用

页码：635 / 639

页数：5

共 27 条

[1]

*BEATL, 1968, REV

[2]

Bottini AA, 2007, ALTEX-ALTERN TIEREXP, V24, P255

[3]

BOZELLECA JF, 2001, PRINCIPLES METHODS T, P1

[4] The development of new concepts for assessing reproductive toxicity applicable to large scale toxicological programmes [J].

Bremer, S. ;

Pellizzer, C. ;

Hoffmann, S. ;

Seidle, T. ;

Hartung, T. .

CURRENT PHARMACEUTICAL DESIGN, 2007, 13 (29) :3047-3058

[5] Toxicology - Transforming environmental health protection [J].

Collins, Francis S. ;

Gray, George M. ;

Bucher, John R. .

SCIENCE, 2008, 319 (5865) :906-907

[6]

Crichton Michael, 2003, CALTECH MICHELIN LEC

[7] Physiologically-based kinetic modelling (PBK modelling): Meeting the 3Rs agenda [J].

d'Yvoire, Michel Bouvier ;

Prieto, Pilar ;

Blaauboer, Bas J. ;

Bois, Frederic Y. ;

Boobis, Alan ;

Brochot, Celine ;

Coecke, Sandra ;

Freidig, Andreas ;

Gundert-Remy, Ursula ;

Hartung, Thomas ;

Jacobs, Miriam N. ;

Lave, Thierry ;

Leahy, David E. ;

Lennernaes, Hans ;

Loizou, George D. ;

Meek, Bette ;

Pease, Camilla ;

Rowland, Malcolm ;

Spendiff, Martin ;

Yang, Jiansong ;

Zeilmaker, Marco .

ATLA-ALTERNATIVES TO LABORATORY ANIMALS, 2007, 35 (06) :661-671

[8]

Doull T, 2001, ANNU REV PHARMACOL, V41, P1

[9]

*EUR COMM, 2001, WHIT PAP STRAT FUT C

[10]

Friedman Thomas, 2007, The World Is Flat: A Brief History of the 21st Century

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