Bruguiesulfurol, a new sulfur compound from Bruguiera gymnorrhiza

被引：28

作者：

Homhual, S

Zhang, HJ

Bunyapraphatsara, N ^{[1
]}

Kondratyuk, TP

Santarsiero, BD

Mesecar, AD

Herunsalee, A

Chaukul, W

Pezzuto, JM

Fong, HHS

机构：

[1] Mahidol Univ, Fac Pharm, Dept Pharmacognosy, Bangkok 10400, Thailand

[2] Univ Illinois, Coll Pharm, Dept Med Chem & Pharmacognosy, Program Collaborat Res Pharmaceut Sci, Chicago, IL USA

[3] Purdue Univ, Coll Pharm Nursing & Hlth Sci, W Lafayette, IN 47907 USA

[4] Univ Illinois, Coll Pharm, Ctr Pharmaceut Biotechnol, Dept Med Chem & Pharmacognosy, Chicago, IL USA

[5] Minist Publ Hlth, Dept Med Sci, Nonthaburi, Thailand

[6] Mahidol Univ, Fac Pharm, Dept Pharmaceut Bot, Bangkok 10700, Thailand

来源：

PLANTA MEDICA | 2006年 / 72卷 / 03期

关键词：

Bruguiera gymnorrhiza; Rhizophoraceae; ARE induction; NF-kappa B inhibition; COX-1; COX-2; dithiosulfonate; bruguiesulfurol; X-ray; NMR;

D O I：

10.1055/s-2005-873171

中图分类号：

Q94 [植物学];

学科分类号：

071001 ;

摘要：

A new cyclic 4-hydroxy-dithiosulfonate, bruguiesulfurol (1), as well as two known 4-hydroxydithiolane 1-oxides, brugierol (2) and isobrugierol (3) were isolated from the flowers of Bruguiera gymnorrhiza. With stably-transfected HepG2 cells, the three isolates activated antioxidant response element (ARE) luciferase activation with (EC50) values of 56.7, 3.7 and 1.8 mu M, respectively. Compounds 2 and 3 also inhibited phorbol ester-induced NF-kappa B (nuclear factor-kappa B) luciferase activity with IC50 Values of 85.0 and 14.5 mu M, respectively. In addition, compound 2 inhibited enzyme cyclooxygenase-2 (COX-2) activity with an IC50 value of 6.1 mu M, The structures of these isolates were determined by spectral data, and that of compound 1 was confirmed by X-ray crystallographic analysis.

引用

页码：255 / 260

页数：6

共 33 条

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