Process research and development of melatonin

被引:19
作者
Prabhakar, C [1 ]
Kumar, NV [1 ]
Reddy, MR [1 ]
Sarma, MR [1 ]
Reddy, GO [1 ]
机构
[1] Dr Reddys Res Fdn, Proc Res & Dev Div, Hyderabad 500050, Andhra Pradesh, India
关键词
D O I
10.1021/op9800820
中图分类号
O69 [应用化学];
学科分类号
081704 ;
摘要
A short, simple, and industrially feasible process for the preparation of melatonin (N-acetyl-5-methoxy tryptamine), starting from phthalimide and 1-bromo-3-chloropropane, in essentially four steps is discussed. The present article elucidates the preparative process along,vith the impurity profile of each intermediate.
引用
收藏
页码:155 / 160
页数:6
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