Mechanisms and consequences of phagocyte adhesion to endothelium

被引:40
作者
Repo, H
Harlan, JM
机构
[1] Univ Helsinki, Haartman Inst, Dept Bacteriol & Immunol, FIN-00014 Helsinki, Finland
[2] Univ Helsinki, Dept Med, FIN-00014 Helsinki, Finland
[3] Univ Washington, Div Hematol, Seattle, WA 98195 USA
关键词
adhesion; integrin; molecules; monocyte; neutrophil; selectin;
D O I
10.3109/07853899909115974
中图分类号
R5 [内科学];
学科分类号
1002 ; 100201 ;
摘要
Leukocyte adhesion to endothelium is essential for the development of an appropriate immune-inflammatory response. The vital importance of leukocyte-endothelial adhesive interactions in host defense and homeostasis is illustrated by the clinical manifestations of patients with congenital defects of leukocyte adhesion functions. However, under some circumstances leukocyte adhesion to endothelium may instead lead to vascular and tissue damage. In recent years, there has been remarkable progress in the understanding of the molecular basis of leukocyte adhesion to endothelium, and this knowledge has led to a new approach to immunomodulation in human disease, ie 'antiadhesion' therapy. This review focuses on cell adhesion molecules mediating adhesion of circulating phagocytes to vascular endothelium, on congenital defects of phagocyte adhesion in man, and on the current status of antiadhesion therapy directed towards phagocyte and endothelial adhesion molecules. We will also consider markers of phagocyte activation, which may provide a means to identify those patients who would benefit most from antiadhesion therapy.
引用
收藏
页码:156 / 165
页数:10
相关论文
共 99 条
[21]   EFFECT OF ASPIRIN ON THROMBIN-INDUCED ADHERENCE OF PLATELETS TO CULTURED-CELLS FROM BLOOD-VESSEL WALL [J].
CZERVIONKE, RL ;
HOAK, JC ;
FRY, GL .
JOURNAL OF CLINICAL INVESTIGATION, 1978, 62 (04) :847-856
[22]   Sepsis and serum cytokine concentrations [J].
Damas, P ;
Canivet, JL ;
DeGroote, D ;
Vrindts, Y ;
Albert, A ;
Franchimont, P ;
Lamy, M .
CRITICAL CARE MEDICINE, 1997, 25 (03) :405-412
[23]   Platelet-mediated lymphocyte delivery to high endothelial venules [J].
Diacovo, TG ;
Puri, KD ;
Warnock, RA ;
Springer, TA ;
vonAndrian, UH .
SCIENCE, 1996, 273 (5272) :252-255
[24]   THE DYNAMIC REGULATION OF INTEGRIN ADHESIVENESS [J].
DIAMOND, MS ;
SPRINGER, TA .
CURRENT BIOLOGY, 1994, 4 (06) :506-517
[25]   Monocyte deactivation in septic patients: Restoration by IFN-gamma treatment [J].
Docke, WD ;
Randow, F ;
Syrbe, U ;
Krausch, D ;
Asadullah, K ;
Reinke, P ;
VolK, HD ;
Kox, W .
NATURE MEDICINE, 1997, 3 (06) :678-681
[26]  
Duncan GS, 1999, J IMMUNOL, V162, P3022
[27]   VONWILLEBRAND-FACTOR MEDIATES PLATELET-ADHESION TO VIRALLY INFECTED ENDOTHELIAL-CELLS [J].
ETINGIN, OR ;
SILVERSTEIN, RL ;
HAJJAR, DP .
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 1993, 90 (11) :5153-5156
[28]   RECURRENT SEVERE INFECTIONS CAUSED BY A NOVEL LEUKOCYTE ADHESION DEFICIENCY [J].
ETZIONI, A ;
FRYDMAN, M ;
POLLACK, S ;
AVIDOR, I ;
PHILLIPS, ML ;
PAULSON, JC ;
GERSHONIBARUCH, R .
NEW ENGLAND JOURNAL OF MEDICINE, 1992, 327 (25) :1789-1792
[29]  
Frenette PS, 1997, THROMB HAEMOSTASIS, V78, P60
[30]   PLATELETS ROLL ON STIMULATED ENDOTHELIUM IN-VIVO - AN INTERACTION MEDIATED BY ENDOTHELIAL P-SELECTIN [J].
FRENETTE, PS ;
JOHNSON, RC ;
HYNES, RO ;
WAGNER, DD .
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 1995, 92 (16) :7450-7454