Au@Pt core/shell nanorods with peroxidase- and ascorbate oxidase-like activities for improved detection of glucose

被引：181

作者：

Liu, Jianbo ^{[2
,3
]}

Hu, Xiaona ^{[2
]}

Hou, Shuai ^{[2
]}

Wen, Tao ^{[2
]}

Liu, Wenqi ^{[2
]}

Zhu, Xing ^{[3
]}

Yin, Jun-Jie ^{[1
]}

Wu, Xiaochun ^{[2
]}

机构：

[1] US FDA, Ctr Food Safety & Appl Nutr, College Pk, MD 20740 USA

[2] Natl Ctr Nanosci & Technol, CAS Key Lab Standardizat & Measurement Nanotechno, Beijing 100190, Peoples R China

[3] Peking Univ, Sch Phys, State Key Lab Mesoscop Phys, Beijing 100871, Peoples R China

来源：

SENSORS AND ACTUATORS B-CHEMICAL | 2012年 / 166卷

基金：

中国国家自然科学基金;

关键词：

Gold nanorods; Platinum; Core/shell nanostructures; Peroxidase mimic; Ascorbate oxidase mimic; Glucose detection; PLATINUM NANOPARTICLES; O-PHENYLENEDIAMINE; GOLD NANORODS; KINETICS; POLYELECTROLYTE; NANOSTRUCTURES; SYSTEM;

D O I：

10.1016/j.snb.2012.03.045

中图分类号：

O65 [分析化学];

学科分类号：

070302 ; 081704 ;

摘要：

Au nanorods @ Pt nanodots core/shell nanostructures, prepared by the Au nanorods (NRs)-mediated growth, exhibit dual functional enzyme-like (peroxidase and oxidase-like) activities. From the viewpoint of enzyme mimics, the relationship between apparent enzyme kinetic parameters and nanomaterials structure is investigated in order to rationally design the catalytic activity. Using peroxidase-like properties of the Au@Pt NRs, the determination of hydrogen peroxide (H2O2) was demonstrated with a limit of detection (LOD) 01 4.5 x 10(-5) M and a linear range of 4.5 x 10(-5)-1 X 10(-3) M using o-phenylenediamine (OPD) as chromogenic substrate. Furthermore, in combination with highly specific reactions provided by natural enzymes, selective detections of glucose and lipophilic cholesterol were demonstrated with similar LODs and linear ranges. Additionally, owing to the specific oxidase-like activity of the Au@Pt NRs (ascorbate oxidase), interference of ascorbic acid in the detection of glucose could be eliminated. In conclusion, considering the flexibility in the design of nanomatererials, there is a lot of space to improve their activity and explore their potential applications, especially in relatively harsh conditions. (C) 2012 Elsevier B.V. All rights reserved.

引用

页码：708 / 714

页数：7

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