Au@Pt nanostructures as oxidase and peroxidase mimetics for use in immunoassays

被引：528

作者：

He, Weiwei ^{[2
,4
]}

Liu, Ying ^{[3
]}

Yuan, Jinshan ^{[3
]}

Yin, Jun-Jie ^{[1
]}

Wu, Xiaochun ^{[2
]}

Hu, Xiaona ^{[2
]}

Zhang, Ke ^{[2
]}

Liu, Jianbo ^{[2
]}

Chen, Chunying ^{[3
]}

Ji, Yinglu ^{[2
]}

Guo, Yuting ^{[2
]}

机构：

[1] US FDA, Ctr Food Safety & Appl Nutr, College Pk, MD 20740 USA

[2] Natl Ctr Nanosci & Technol, CAS Key Lab Standardizat & Measurement Nanotechno, Beijing 100190, Peoples R China

[3] Natl Ctr Nanosci & Technol, CAS Key Lab Biol Effects Nanomat & Nanosafety, Beijing 100190, Peoples R China

[4] Xuchang Univ, Inst Surface Micro & Nano Mat, Xuchang 461000, Peoples R China

来源：

BIOMATERIALS | 2011年 / 32卷 / 04期

基金：

中国国家自然科学基金;

关键词：

Platinum; Nanostructures; Oxidase; Peroxidase; Catalase; Immunoassays; OXYGEN REDUCTION REACTION; GOLD NANORODS; HYDROGEN-PEROXIDE; GLUCOSE DETECTION; PLATINUM NANOPARTICLES; CATALYTIC-ACTIVITY; SUPEROXIDE ANION; CONTRAST AGENTS; MECHANISM; GROWTH;

D O I：

10.1016/j.biomaterials.2010.09.040

中图分类号：

R318 [生物医学工程];

学科分类号：

0831 ;

摘要：

In this paper, we demonstrated that Au nanorods coated with a shell composed of Pt nanodots (Au@Pt nanostructures) exhibited intrinsic oxidase-like, peroxidase-like and catalase-like activity, catalyzing oxygen and hydrogen peroxide reduction and the dismutation decomposition of hydrogen peroxide to produce oxygen. Based on these findings, we established an Au@Pt nanostructures based enzyme linked immunosorbent assay (ELISA) for the detection of mouse interleukin 2 (IL-2). In comparison with natural enzymes, Au@Pt nanostructures have advantages of low cost, easy preparation, better stability, and tunable catalytic activity (compared with HRP), which make them a promising enzyme mimetic candidate and may find potential applications in biocatalysis, bioassays, and nano-biomedicine such as reactive oxygen species (ROS)-related fields (anti-aging and therapeutics for neurodegenerative diseases and cancers). (c) 2010 Elsevier Ltd. All rights reserved.

引用

页码：1139 / 1147

页数：9

共 41 条

[1]

[Anonymous], 2006, ANGEW CHEM, DOI DOI 10.1002/ANGE.200603068

[2] Oxygen reduction reaction kinetics and mechanism on platinum nanoparticles inside Nafion® [J].

Antoine, O ;

Bultel, Y ;

Durand, R .

JOURNAL OF ELECTROANALYTICAL CHEMISTRY, 2001, 499 (01) :85-94

[3] Oxidase-Like Activity of Polymer-Coated Cerium Oxide Nanoparticles [J].

Asati, Atul ;

Santra, Santimukul ;

Kaittanis, Charalambos ;

Nath, Sudip ;

Perez, J. Manuel .

ANGEWANDTE CHEMIE-INTERNATIONAL EDITION, 2009, 48 (13) :2308-2312

[4] Magnetite-loaded carrier erythrocytes as contrast agents for magnetic resonance imaging [J].

Braehler, M. ;

Georgieva, R. ;

Buske, N. ;

Mueller, A. ;

Mueller, S. ;

Pinkernelle, J. ;

Teichgraeber, U. ;

Voigt, A. ;

Baeumler, H. .

NANO LETTERS, 2006, 6 (11) :2505-2509

[5] Electrocatalytic reduction of hydrogen peroxide at platinum microparticles dispersed in a poly(o-phenylenediamine) film [J].

Cai, LT ;

Chen, HY .

SENSORS AND ACTUATORS B-CHEMICAL, 1999, 55 (01) :14-18

[6] Nanostructured FeS as a Mimic Peroxidase for Biocatalysis and Biosensing [J].

Dai, Zhihui ;

Liu, Shaohua ;

Bao, Jianchun ;

Jui, Huangxian .

CHEMISTRY-A EUROPEAN JOURNAL, 2009, 15 (17) :4321-4326

[7] Gold nanorods coated with multilayer polyelectrolyte as contrast agents for multimodal imaging [J].

Ding, Hong ;

Yong, Ken-Tye ;

Roy, Indrajit ;

Pudavar, Haridas E. ;

Law, Wing Cheung ;

Bergey, Earl J. ;

Prasad, Paras N. .

JOURNAL OF PHYSICAL CHEMISTRY C, 2007, 111 (34) :12552-12557

[8] Well-Controlled Synthesis of Au@Pt Nanostructures by Gold-Nanorod-Seeded Growth [J].

Feng, Lili ;

Wu, Xiaochun ;

Ren, Lirong ;

Xiang, Yanjuan ;

He, Weiwei ;

Zhang, Ke ;

Zhou, Weiya ;

Xie, Sishen .

CHEMISTRY-A EUROPEAN JOURNAL, 2008, 14 (31) :9764-9771

[9] Covalent hemin-DNA adducts for generating a novel class of artificial heme enzymes [J].

Fruk, L ;

Niemeyer, CM .

ANGEWANDTE CHEMIE-INTERNATIONAL EDITION, 2005, 44 (17) :2603-2606

[10] Magnetite Nanoparticle-Linked Immunosorbent Assay [J].

Gao, Lizeng ;

Wu, Jiamin ;

Lyle, Sarah ;

Zehr, Keith ;

Cao, Liangliang ;

Gao, Di .

JOURNAL OF PHYSICAL CHEMISTRY C, 2008, 112 (44) :17357-17361

← 1 2 3 4 5 →