Heterogeneous macrolide resistance and gene conversion in the pneumococcus

被引：15

作者：

Wolter, N

Smith, AM

Farrell, DJ

Klugman, KP

机构：

[1] Natl Inst Communicable Dis, Resp & Meningeal Pathogens Res Unit, ZA-2131 Johannesburg, South Africa

[2] MRC, Natl Inst Communicable Dis, Resp & Meningeal Pathogens Res Unit, Johannesburg, South Africa

[3] Univ Witwatersrand, Natl Inst Communicable Dis, Resp & Meningeal Pathogens Res Unit, Johannesburg, South Africa

[4] GR Micro Ltd, London, England

[5] Emory Univ, Sch Med, Rollins Sch Publ Hlth, Dept Global Hlth, Atlanta, GA 30322 USA

[6] Emory Univ, Sch Med, Div Infect Dis, Atlanta, GA 30322 USA

来源：

ANTIMICROBIAL AGENTS AND CHEMOTHERAPY | 2006年 / 50卷 / 01期

基金：

英国惠康基金;

关键词：

D O I：

10.1128/AAC.50.1.359-361.2006

中图分类号：

Q93 [微生物学];

学科分类号：

071005 ; 100705 ;

摘要：

A macrolide-resistant clinical isolate of Streptococcus pneumoniae with 23S rRNA mutations showed a heterogeneous phenotype and genotype. The mutant 23S rRNA genes from this isolate transformed susceptible strain R6 to resistance. Culture of resistant strain R6 in the absence of antibiotic pressure showed gene conversion to occur between the four 23S rRNA alleles, resulting in reversion to susceptibility with the resistant phenotype showing a fitness cost. These data explain the disappearance on subculture of heterogeneous macrolide resistance in the pneumococcus.

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收藏

页码：359 / 361

页数：3

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