The histone LSD1 demethylase in stemness and cancer transcription programs

被引：214

作者：

Amente, Stefano ^{[1
]}

Lania, Luigi ^{[1
]}

Majello, Barbara ^{[1
]}

机构：

[1] Univ Naples Federico II, Dept Biol, I-80126 Naples, Italy

来源：

BIOCHIMICA ET BIOPHYSICA ACTA-GENE REGULATORY MECHANISMS | 2013年 / 1829卷 / 10期

关键词：

LSD1; Chromatin; Histone modification; Cancer; Stem cell; SELF-RENEWAL; REGULATORY CIRCUITRY; GENE ACTIVATION; DNA OXIDATION; TAL1; FUNCTION; PLURIPOTENCY; METHYLATION; PROTEINS; NETWORK; LYSINE-SPECIFIC-DEMETHYLASE-1;

D O I：

10.1016/j.bbagrm.2013.05.002

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

070307 [化学生物学]; 071010 [生物化学与分子生物学];

摘要：

DNA and histone chromatin modifying enzymes play a crucial role in chromatin remodeling in several biological processes. Lysine-specific demethylase 1 (LSD1), the first identified histone demethylase, is a relevant player in the regulation of a broad spectrum of biological processes including development, cellular differentiation, embryonic pluripotency and cancer. Here, we review recent insights on the role of LSD1 activity in chromatin regulatory complexes, its functional role in the epigenetic changes during embryonic development, in the establishment and maintenance of sternness and during cancer progression. (C) 2013 The Authors. Published by Elsevier B.V. All rights reserved.

引用

页码：981 / 986

页数：6

共 77 条

[1]

LSD1 and pluripotency A new player in the network [J].

Adamo, Antonio ;

Barrero, Maria J. ;

Izpisua Belmonte, Juan Carlos .

CELL CYCLE, 2011, 10 (19) :3215-3216

[2]

LSD1 regulates the balance between self-renewal and differentiation in human embryonic stem cells [J].

Adamo, Antonio ;

Sese, Borja ;

Boue, Stephanie ;

Castano, Julio ;

Paramonov, Ida ;

Barrero, Maria J. ;

Izpisua Belmonte, Juan Carlos .

NATURE CELL BIOLOGY, 2011, 13 (06) :652-U265

[3]

LSD1-mediated demethylation of histone H3 lysine 4 triggers Myc-induced transcription [J].

Amente, S. ;

Bertoni, A. ;

Morano, A. ;

Lania, L. ;

Avvedimento, E. V. ;

Majello, B. .

ONCOGENE, 2010, 29 (25) :3691-3702

[4]

DNA oxidation drives Myc mediated transcription [J].

Amente, Stefano ;

Lania, Luigi ;

Avvedimento, Enrico Vittorio ;

Majello, Barbara .

CELL CYCLE, 2010, 9 (15) :3002-3004

[5]

Biochemical, Structural, and Biological Evaluation of Tranylcypromine Derivatives as Inhibitors of Histone Demethylases LSD1 and LSD2 [J].

Binda, Claudia ;

Valente, Sergio ;

Romanenghi, Mauro ;

Pilotto, Simona ;

Cirilli, Roberto ;

Karytinos, Aristotele ;

Ciossani, Giuseppe ;

Botrugno, Oronza A. ;

Forneris, Federico ;

Tardugno, Maria ;

Edmondson, Dale E. ;

Minucci, Saverio ;

Mattevi, Andrea ;

Mai, Antonello .

JOURNAL OF THE AMERICAN CHEMICAL SOCIETY, 2010, 132 (19) :6827-6833

[6]

Function of leukemogenic mixed lineage leukemia 1 (MLL) fusion proteins through distinct partner protein complexes [J].

Biswas, Debabrata ;

Milne, Thomas A. ;

Basrur, Venkatesha ;

Kim, Jaehoon ;

Elenitoba-Johnson, Kojo S. J. ;

Allis, C. David ;

Roeder, Robert G. .

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 2011, 108 (38) :15751-15756

[7]

Histone Lysine Methylation Dynamics: Establishment, Regulation, and Biological Impact [J].

Black, Joshua C. ;

Van Rechem, Capucine ;

Whetstine, Johnathan R. .

MOLECULAR CELL, 2012, 48 (04) :491-507

[8]

Core transcriptional regulatory circuitry in human embryonic stem cells [J].

Boyer, LA ;

Lee, TI ;

Cole, MF ;

Johnstone, SE ;

Levine, SS ;

Zucker, JR ;

Guenther, MG ;

Kumar, RM ;

Murray, HL ;

Jenner, RG ;

Gifford, DK ;

Melton, DA ;

Jaenisch, R ;

Young, RA .

CELL, 2005, 122 (06) :947-956

[9]

LIF/STAT3 controls ES cell self-renewal and pluripotency by a Myc-dependent mechanism [J].

Cartwright, P ;

McLean, C ;

Sheppard, A ;

Rivett, D ;

Jones, K ;

Dalton, S .

DEVELOPMENT, 2005, 132 (05) :885-896

[10]

Integration of external signaling pathways with the core transcriptional network in embryonic stem cells [J].

Chen, Xi ;

Xu, Han ;

Yuan, Ping ;

Fang, Fang ;

Huss, Mikael ;

Vega, Vinsensius B. ;

Wong, Eleanor ;

Orlov, Yuriy L. ;

Zhang, Weiwei ;

Jiang, Jianming ;

Loh, Yuin-Han ;

Yeo, Hock Chuan ;

Yeo, Zhen Xuan ;

Narang, Vipin ;

Govindarajan, Kunde Ramamoorthy ;

Leong, Bernard ;

Shahab, Atif ;

Ruan, Yijun ;

Bourque, Guillaume ;

Sung, Wing-Kin ;

Clarke, Neil D. ;

Wei, Chia-Lin ;

Ng, Huck-Hui .

CELL, 2008, 133 (06) :1106-1117

← 1 2 3 4 5 6 7 8 →