A novel and mild solid phase hydroperoxydeamination reaction

被引：5

作者：

Bonnet, D

Rommens, C

Gras-Masse, H

Melnyk, O

机构：

[1] Inst Pasteur, Inst Biol, F-59021 Lille, France

[2] Univ Lille 2, F-59021 Lille, France

来源：

TETRAHEDRON LETTERS | 1999年 / 40卷 / 41期

关键词：

hydroperoxydeamination; N-electrophilic amination; solid phase; PEGA resin; 6-hydroxynorleucine; HR MAS NMR;

D O I：

10.1016/S0040-4039(99)01414-8

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

The unnatural amino acid Lys(NH2), easily incorporated into a peptidyl-PEGA resin by N-electrophilic amination of the epsilon-amino group, was cleanly transformed on the solid phase into 6-hydroxynorleucine by air oxidation in the presence of bicarbonate ions followed by reduction of the hydroperoxy intermediate with a water soluble phosphine. (C) 1999 Elsevier Science Ltd. All rights reserved.

引用

页码：7315 / 7318

页数：4

共 15 条

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