Novel three-step hydroxy-deamination sequence: Conversion of lysine to 6-hydroxynorleucine derivatives

被引：11

作者：

Nevill, CR ^{[1
]}

Angell, PT ^{[1
]}

机构：

[1] Hoechst Marion Roussel, Chem Dev, Cincinnati, OH 45215 USA

来源：

TETRAHEDRON LETTERS | 1998年 / 39卷 / 32期

关键词：

D O I：

10.1016/S0040-4039(98)01142-3

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

Oxidation of carbamates with catalytic RuO4, generated from RuO4, and NaBrO3, provides the corresponding acyl carbamates, which can be reduced with NaBH4 to provide alcohols. Application of this methodology to L-lysine provides (S)-6-hydroxynorleucine derivatives. (C) 1998 Elsevier Science Ltd. All rights reserved.

引用

页码：5671 / 5674

页数：4

共 16 条

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