Polymorphism of human telomeric quadruplex structures

被引:356
作者
Dai, Jixun [1 ]
Carver, Megan [1 ]
Yang, Danzhou [1 ,2 ,3 ]
机构
[1] Univ Arizona, Coll Pharm, Tucson, AZ 85721 USA
[2] Arizona Canc Ctr, Tucson, AZ 85724 USA
[3] Univ Arizona, Inst BIO5, Tucson, AZ 85721 USA
关键词
human telomere; G-quadruplex; structure polymorphism; potassium structure; anticancer drug target; NMR;
D O I
10.1016/j.biochi.2008.02.026
中图分类号
Q5 [生物化学]; Q7 [分子生物学];
学科分类号
071010 ; 081704 ;
摘要
Human telomeric DNA consists of tandem repeats of the sequence cl(TTAGGG). Compounds that can stabilize the intramolecular DNA G-quadruplexes formed in the human telomeric sequence have been shown to inhibit the activity of telomerase and telomere maintenance, thus the telomeric DNA G-quadruplex has been considered as an attractive target for cancer therapeutic intervention. Knowledge of intramolecular human telomeric G-quadruplex structure(s) formed under physiological conditions is important for structure-based rational drug design and thus has been the subject of intense investigation. This review will give an overview of recent progress on the intramolecular human telomeric G-quadruplex structures formed in K+ solution. It will also give insight into the structure polymorphism. of human telomeric sequences and its implications for drug targeting. (C) 2008 Elsevier Masson SAS. All fights reserved.
引用
收藏
页码:1172 / 1183
页数:12
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