Polymorphism of human telomeric quadruplex structures
被引:356
作者:
Dai, Jixun
论文数: 0引用数: 0
h-index: 0
机构:
Univ Arizona, Coll Pharm, Tucson, AZ 85721 USAUniv Arizona, Coll Pharm, Tucson, AZ 85721 USA
Dai, Jixun
[1
]
Carver, Megan
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h-index: 0
机构:
Univ Arizona, Coll Pharm, Tucson, AZ 85721 USAUniv Arizona, Coll Pharm, Tucson, AZ 85721 USA
Carver, Megan
[1
]
Yang, Danzhou
论文数: 0引用数: 0
h-index: 0
机构:
Univ Arizona, Coll Pharm, Tucson, AZ 85721 USA
Arizona Canc Ctr, Tucson, AZ 85724 USA
Univ Arizona, Inst BIO5, Tucson, AZ 85721 USAUniv Arizona, Coll Pharm, Tucson, AZ 85721 USA
Yang, Danzhou
[1
,2
,3
]
机构:
[1] Univ Arizona, Coll Pharm, Tucson, AZ 85721 USA
human telomere;
G-quadruplex;
structure polymorphism;
potassium structure;
anticancer drug target;
NMR;
D O I:
10.1016/j.biochi.2008.02.026
中图分类号:
Q5 [生物化学];
Q7 [分子生物学];
学科分类号:
071010 ;
081704 ;
摘要:
Human telomeric DNA consists of tandem repeats of the sequence cl(TTAGGG). Compounds that can stabilize the intramolecular DNA G-quadruplexes formed in the human telomeric sequence have been shown to inhibit the activity of telomerase and telomere maintenance, thus the telomeric DNA G-quadruplex has been considered as an attractive target for cancer therapeutic intervention. Knowledge of intramolecular human telomeric G-quadruplex structure(s) formed under physiological conditions is important for structure-based rational drug design and thus has been the subject of intense investigation. This review will give an overview of recent progress on the intramolecular human telomeric G-quadruplex structures formed in K+ solution. It will also give insight into the structure polymorphism. of human telomeric sequences and its implications for drug targeting. (C) 2008 Elsevier Masson SAS. All fights reserved.
机构:
Univ Colorado, Howard Hughes Med Inst, Dept Chem & Biochem, Boulder, CO 80309 USAUniv Colorado, Howard Hughes Med Inst, Dept Chem & Biochem, Boulder, CO 80309 USA
Baumann, P
;
Cech, TR
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机构:
Univ Colorado, Howard Hughes Med Inst, Dept Chem & Biochem, Boulder, CO 80309 USAUniv Colorado, Howard Hughes Med Inst, Dept Chem & Biochem, Boulder, CO 80309 USA
机构:
Univ Colorado, Howard Hughes Med Inst, Dept Chem & Biochem, Boulder, CO 80309 USAUniv Colorado, Howard Hughes Med Inst, Dept Chem & Biochem, Boulder, CO 80309 USA
Baumann, P
;
Cech, TR
论文数: 0引用数: 0
h-index: 0
机构:
Univ Colorado, Howard Hughes Med Inst, Dept Chem & Biochem, Boulder, CO 80309 USAUniv Colorado, Howard Hughes Med Inst, Dept Chem & Biochem, Boulder, CO 80309 USA