Metalation of 2-chloromethyl-2-oxazolines: Synthesis of 1,2,3-tris(oxazolinyl)cyclopropanes and derivatives

被引：30

作者：

Capriati, V ^{[1
]}

Florio, S ^{[1
]}

Luisi, R ^{[1
]}

Rocchetti, MT ^{[1
]}

机构：

[1] Univ Bari, Dipartimento Farmaco Chim, Ctr CNR, MISO, I-70125 Bari, Italy

来源：

JOURNAL OF ORGANIC CHEMISTRY | 2002年 / 67卷 / 03期

关键词：

D O I：

10.1021/jo015962i

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

2-Chloromethyl-2-oxazoline converts cleanly into trans-1,2,3-tris(oxazolinyl)cyclopropane upon treatment with strong bases such as LDA or KN(SiMe3)(2). Deprotonation of the above cyclopropane followed by the addition of electrophiles allows the preparation of more functionalized tris-(oxazolinyl)cyclopropanes.

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页码：759 / 763

页数：5

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