Measuring and using light in the melanopsin age

被引：848

作者：

Lucas, Robert J. ^{[1
]}

Peirson, Stuart N. ^{[2
]}

Berson, David M. ^{[3
]}

Brown, Timothy M. ^{[1
]}

Cooper, Howard M. ^{[4
]}

Czeisler, Charles A. ^{[5
,6
]}

Figueiro, Mariana G. ^{[7
]}

Gamlin, Paul D. ^{[8
]}

Lockley, Steven W. ^{[5
,6
]}

O'Hagan, John B. ^{[9
]}

Price, Luke L. A. ^{[9
]}

Provencio, Ignacio ^{[10
]}

Skene, Debra J. ^{[11
]}

Brainard, George C. ^{[12
]}

机构：

[1] Univ Manchester, Fac Life Sci, Manchester M13 9PT, Lancs, England

[2] Univ Oxford, Nuffield Dept Clin Neurosci, Nuffield Lab Ophthalmol, Oxford OX3 9DU, England

[3] Brown Univ, Dept Neurosci, Providence, RI 02912 USA

[4] INSERM, Stem Cell & Brain Res Inst 846, Dept Chronobiol, F-69500 Bron, France

[5] Harvard Univ, Sch Med, Div Sleep Med, Boston, MA USA

[6] Brigham & Womens Hosp, Dept Med, Div Sleep Med, Boston, MA 02115 USA

[7] Rensselaer Polytech Inst, Lighting Res Ctr, Troy, NY 12180 USA

[8] Univ Alabama Birmingham, Dept Ophthalmol, Birmingham, AL 35294 USA

[9] Publ Hlth England, Didcot OX11 0RQ, Oxon, England

[10] Univ Virginia, Dept Biol, Charlottesville, VA USA

[11] Univ Surrey, Fac Hlth & Med Sci, Guildford GU2 7XH, Surrey, England

[12] Thomas Jefferson Univ, Dept Neurol, Philadelphia, PA 19107 USA

来源：

TRENDS IN NEUROSCIENCES | 2014年 / 37卷 / 01期

基金：

英国生物技术与生命科学研究理事会;

关键词：

RETINAL GANGLION-CELL; SHORT-WAVELENGTH SENSITIVITY; HUMAN MELATONIN REGULATION; NON-CONE; NON-ROD; NONVISUAL RESPONSES; ACTION SPECTRUM; PUPILLARY; PHOTORECEPTORS; PHOTOTRANSDUCTION;

D O I：

10.1016/j.tins.2013.10.004

中图分类号：

Q189 [神经科学];

学科分类号：

071006 ;

摘要：

Light is a potent stimulus for regulating circadian, hormonal, and behavioral systems. In addition, light therapy is effective for Certain affective disorders, sleep problems, and circadian rhythm disruption. These biological and behavioral effects of light are influenced by a distinct photoreceptor in the eye, melanopsin-containing intrinsically photosensitive retinal ganglion cells (ipRGCs), in addition to conventional rods and cones. We summarize the neurophysiology of this newly described sensory pathway and consider implications for the measurement, production, and application of light. A new light-measurement strategy taking account of the complex photoreceptive inputs to these non-visual responses is proposed for use by researchers, and simple suggestions for artificial/architectural lighting are provided for regulatory authorities, lighting manufacturers, designers, and engineers.

引用

页码：1 / 9

页数：9

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