Synthesis, structure, and reactivity of enediyne macrocycles

被引：46

作者：

Konig, B ^{[1
]}

Pitsch, W ^{[1
]}

Thondorf, I ^{[1
]}

机构：

[1] UNIV HALLE WITTENBERG,INST BIOCHEM,D-06099 HALLE,GERMANY

来源：

JOURNAL OF ORGANIC CHEMISTRY | 1996年 / 61卷 / 13期

关键词：

D O I：

10.1021/jo9600971

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

The reaction of bis-propargyl bromide enediyne 4 with weakly basic nucleophiles allows the facile synthesis of acyclic and macrocyclic enediynes. Depending on the bis-nucleophile employed, 12- to 16-membered enediyne macrocycles were obtained. The thermal stability of the new cyclic enediynes was investigated by differential scanning calorimetry. Upon coordination of the macrocycle 5c with Hg(O2CCF3)(2), a drop of the enediyne cyclization temperature of nearly 100 K was observed.

引用

页码：4258 / 4261

页数：4

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