Prostaglandins and bone: physiology and pathophysiology

被引：133

作者：

Raisz, LG ^{[1
]}

机构：

[1] Univ Connecticut, Ctr Hlth, Gen Clin Res Ctr, Farmington, CT 06030 USA

来源：

OSTEOARTHRITIS AND CARTILAGE | 1999年 / 7卷 / 04期

关键词：

prostaglandin; bone; osteoarthritis;

D O I：

10.1053/joca.1998.0230

中图分类号：

R826.8 [整形外科学]; R782.2 [口腔颌面部整形外科学]; R726.2 [小儿整形外科学]; R62 [整形外科学（修复外科学）];

学科分类号：

摘要：

Prostaglandins (PGs) are potent stimulators of bone formation and resorption and are produced by bone cells. PGs also have inhibitory effects on fully differentiated osteoblasts and osteoclasts. This complex, multifunctional regulation is probably mediated by different PG receptors. Endogenous PGs in bone are produced largely by induction of COX-2, which is highly regulated by hormones and local factors. The development of specific agonists and antagonists for PG receptors and for COX-2 should allow us to define the physiologic and pathophysiologic roles of PGs more precisely and develop new therapeutic approaches to metabolic and inflammatory disorders of the skeleton.

引用

页码：419 / 421

页数：3

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