Desymmetrization of meso-cyclopenten-cis-1,4-diol to 4-(R)-hydroxycyclopent-2-en-1-(S)-acetate by irreversible transesterification using Chirazyme®

被引：15

作者：

Ghorpade, SR ^{[1
]}

Kharul, RK ^{[1
]}

Joshi, RR ^{[1
]}

Kalkote, UR ^{[1
]}

Ravindranathan, T ^{[1
]}

机构：

[1] Natl Chem Lab, Div Organ Chem, Pune 411008, Maharashtra, India

来源：

TETRAHEDRON-ASYMMETRY | 1999年 / 10卷 / 05期

关键词：

D O I：

10.1016/S0957-4166(99)00068-3

中图分类号：

O61 [无机化学];

学科分类号：

070301 ; 081704 ;

摘要：

The parameter optimization study for the desymmetrization of meso-cyclopenten-1,4-diol 1 through irreversible transesterification using an immobilized lipase from Mucor meihei, i.e., Lipozyme(R)/Chirazyme(R) is presented. The enzyme was studied for the transesterification of 1 in various organic solvents by varying reaction parameters such as the nature of acyl donor, temperature, enzyme quantity etc., to afford optically active 4-(R)-hydroxycyclopent-2-en-1-(S)-acetate 2 of >98% enantiomeric excess in >60% yield. (C) 1999 Elsevier Science Ltd. All rights reserved.

引用

页码：891 / 899

页数：9

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