Bactericidal/permeability-increasing protein (BPI) and BPI homologs at mucosal sites

被引：70

作者：

Canny, Geraldine ^{[1
]}

Levy, Ofer ^{[2
,3
]}

机构：

[1] CHUV, Dept Gynecol Obstet & Med Genet, CH-1011 Lausanne, Switzerland

[2] Childrens Hosp, Div Infect Dis, Boston, MA 02115 USA

[3] Harvard Univ, Sch Med, Boston, MA 02115 USA

来源：

TRENDS IN IMMUNOLOGY | 2008年 / 29卷 / 11期

基金：

瑞士国家科学基金会;

关键词：

D O I：

10.1016/j.it.2008.07.012

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

At mucosal surfaces, we must co-exist with a high density of diverse microorganisms; therefore, protection against these occurs on multiple levels. Leukocyte- and epithelial derived-anti microbial peptides and proteins (AMPs) comprise an essential component of immune defense. These molecules possess antibacterial, antifungal and signalling properties and probably contribute to defence and maintenance of homeostasis between the host and commensal microorganisms. Among these AMPs is bactericidal/permeability-increasing protein (BPI), an antimicrobial protein with potent endotoxin-neutralising activity, and several homologs. This review explores the roles of BPI and and its homologs at the mucosal interface. Congeners of BPI are under biopharmaceutical development as novel anti-infective agents, highlighting the potential therapeutic relevance of this protein family.

引用

页码：541 / 547

页数：7

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