Thinking combinatorially

被引：13

作者：

Kauffman, S

Ellington, AD

机构：

[1] Santa Fe Inst, Santa Fe, NM 87501 USA

[2] CIStem Mol, Austin, TX 78712 USA

[3] Univ Texas, Dept Biochem & Chem, Austin, TX 78712 USA

来源：

CURRENT OPINION IN CHEMICAL BIOLOGY | 1999年 / 3卷 / 03期

关键词：

D O I：

10.1016/S1367-5931(99)80040-4

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Biopolymers and chemical compounds with novel functions can be selected or screened from randomized libraries. Recently, it has become possible to augment the functions of biopolymers via the conjugation or incorporation of unnatural chemical moieties. In the future, it should prove possible to engineer systems that can self-evolve and thereby reveal unexpected emergent properties.

引用

收藏

页码：256 / 259

页数：4

相关论文

共 36 条

[1] DIRECT SELECTION OF ANTIBODIES THAT COORDINATE METALS FROM SEMISYNTHETIC COMBINATORIAL LIBRARIES [J].

BARBAS, CF ;

ROSENBLUM, JS ;

LERNER, RA .

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 1993, 90 (14) :6385-6389

[2] PROTECTION AGAINST MYCOPLASMA-INFECTION USING EXPRESSION-LIBRARY IMMUNIZATION [J].

BARRY, MA ;

LAI, WC ;

JOHNSTON, SA .

NATURE, 1995, 377 (6550) :632-635

[3] EMERGENCE OF A REPLICATING SPECIES FROM AN IN-VITRO RNA EVOLUTION REACTION [J].

BREAKER, RR ;

JOYCE, GF .

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 1994, 91 (13) :6093-6097

[4] PEPTIDES ON PHAGE - A VAST LIBRARY OF PEPTIDES FOR IDENTIFYING LIGANDS [J].

CWIRLA, SE ;

PETERS, EA ;

BARRETT, RW ;

DOWER, WJ .

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 1990, 87 (16) :6378-6382

[5] HYPERCYCLE - PRINCIPLE OF NATURAL SELF-ORGANIZATION .A. EMERGENCE OF HYPERCYCLE [J].

EIGEN, M ;

SCHUSTER, P .

NATURWISSENSCHAFTEN, 1977, 64 (11) :541-565

[6] MOLECULAR QUASI-SPECIES [J].

EIGEN, M ;

MCCASKILL, J ;

SCHUSTER, P .

JOURNAL OF PHYSICAL CHEMISTRY, 1988, 92 (24) :6881-6891

[7] INVITRO SELECTION OF RNA MOLECULES THAT BIND SPECIFIC LIGANDS [J].

ELLINGTON, AD ;

SZOSTAK, JW .

NATURE, 1990, 346 (6287) :818-822

[8]

GEYSEN H, 1984, Patent No. 4708871

[9] USE OF PEPTIDE-SYNTHESIS TO PROBE VIRAL-ANTIGENS FOR EPITOPES TO A RESOLUTION OF A SINGLE AMINO-ACID [J].

GEYSEN, HM ;

MELOEN, RH ;

BARTELING, SJ .

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA-BIOLOGICAL SCIENCES, 1984, 81 (13) :3998-4002

[10] Computational protein engineering [J].

Hellinga, HW .

NATURE STRUCTURAL BIOLOGY, 1998, 5 (07) :525-527

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