Cytotoxic constituents of the stem bark of Neolitsea acuminatissima

被引：59

作者：

Chang, FR

Hsieh, TJ

Huang, TL

Chen, CY

Kuo, RY

Chang, YC

Chiu, HF

Wu, YC ^{[1
]}

机构：

[1] Kaohsiung Med Univ, Grad Inst Nat Prod, Kaohsiung 807, Taiwan

[2] Fooyin Inst Technol, Dept Nursing, Kaohsiung 831, Taiwan

[3] Kao Yuan Inst Technol, Dept Chem Engn, Kaohsiung 821, Taiwan

来源：

JOURNAL OF NATURAL PRODUCTS | 2002年 / 65卷 / 03期

关键词：

D O I：

10.1021/np010236w

中图分类号：

Q94 [植物学];

学科分类号：

071001 ;

摘要：

Three new eudesmanolide sesquiterpenes, neolitacumone A-C (1-3), and one new benzylisoquinoline alkaloid, neolitacumonine (5), along with 27 known compounds were isolated from the stem bark of Neolitsea acuminatissima. The structures of compounds 1-3 and 5 were established on the basis of spectral and chemical evidence. Compounds 2, 3, and 20 were selectively inhibitory to Hep 2,2,15 cells with IC50 values in the range 0.24-0.04,mug/mL. Compound 20 was marginally cytotoxic to Hep G(2) cells.

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页码：255 / 258

页数：4

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