An Inflammatory Profile Correlates With Decreased Frequency of Cytotoxic Cells in Coronavirus Disease 2019

被引：91

作者：

Bordoni, Veronica ^{[1
]}

Sacchi, Alessandra ^{[1
]}

Cimini, Eleonora ^{[1
]}

Notari, Stefania ^{[1
]}

Grassi, Germana ^{[1
]}

Tartaglia, Eleonora ^{[1
]}

Casetti, Rita ^{[1
]}

Giancola, Maria Letizia ^{[1
]}

Bevilacqua, Nazario ^{[1
]}

Maeurer, Markus ^{[2
,3
]}

Zumla, Alimuddin ^{[4
,5
]}

Locatelli, Franco ^{[6
]}

De Benedetti, Fabrizio ^{[6
]}

Palmieri, Fabrizio ^{[1
]}

Marchioni, Luisa ^{[1
]}

Capobianchi, Maria R. ^{[1
]}

D'Offizi, Gianpiero ^{[1
]}

Petrosillo, Nicola ^{[1
]}

Antinori, Andrea ^{[1
]}

Nicastri, Emanuele ^{[1
]}

Ippolito, Giuseppe ^{[1
]}

Agrati, Chiara ^{[1
]}

机构：

[1] Ist Ricovero & Cura Carattere Sci, Natl Inst Infect Dis Lazzaro Spallanzani, Rome, Italy

[2] Champalimaud Ctr Unknown, Immunotherapy Programme, Lisbon, Portugal

[3] Johannes Gutenberg Univ Mainz, I Med Clin, Mainz, Germany

[4] UCL, Div Infect & Immun, London, England

[5] Univ Coll London Hosp NHS Fdn Trust, Natl Inst Hlth Res Biomed Res Ctr, London, England

[6] Ist Ricovero & Cura Carattere Sci, Osped Pediatr Bambino Gesu, Rome, Italy

来源：

CLINICAL INFECTIOUS DISEASES | 2020年 / 71卷 / 16期

基金：

欧盟地平线“2020”;

关键词：

COVID-19; inflammation; NK cells; cytotoxic cells; MDSC;

D O I：

10.1093/cid/ciaa577

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

071005 [微生物学]; 100108 [医学免疫学];

摘要：

Increased production of inflammatory cytokines and myeloid-derived suppressor cells occurs in patients with coronavirus disease 2019. These inversely correlated with perforin-expressing natural killer (NK) and CD3(+) T cells. We observed a lower number of perforin-expressing NK cells in intensive care unit (ICU) patients compared with non-ICU patients, suggesting an impairment of the immune cytotoxic arm as a pathogenic mechanism.

引用

页码：2272 / 2275

页数：4

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