Sin3: Master scaffold and transcriptional corepressor

被引：198

作者：

Grzenda, Adrienne

Lomberk, Gwen

Zhang, Jin-San

Urrutia, Raul ^{[1
]}

机构：

[1] Mayo Clin, Lab Chromatin Dynam & Epigenet, Gastroenterol Res Unit, Dept Biochem & Mol Biol, Rochester, MN 55905 USA

来源：

BIOCHIMICA ET BIOPHYSICA ACTA-GENE REGULATORY MECHANISMS | 2009年 / 1789卷 / 6-8期

关键词：

Sin3; Transcription; Deacetylation; Repression; Histone; Chromatin; HISTONE DEACETYLASE COMPLEX; CO-REPRESSOR COMPLEX; SACCHAROMYCES-CEREVISIAE; FAMILY PROTEINS; BINDING PROTEIN; PAH2; DOMAIN; IN-VIVO; PERICENTRIC HETEROCHROMATIN; SIN3/HISTONE DEACETYLASE; NEGATIVE REGULATOR;

D O I：

10.1016/j.bbagrm.2009.05.007

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Sin3 was isolated over two decades ago as a negative regulator of transcription in budding yeast. Subsequent research has established the protein as a master transcriptional scaffold and corepressor capable of transcriptional silencing via associated histone deacetylases (HDACs). The core Sin3-HDAC complex interacts with a wide variety of repressors and corepressors, providing flexibility and expanded specificity in modulating chromatin structure and transcription. As a result, the Sin3/HDAC complex is involved in an array of biological and cellular processes, including cell cycle progression, genomic stability, embryonic development, and homeostasis. Abnormal recruitment of this complex or alteration of its enzymatic activity has been implicated in neoplastic transformation. (C) 2009 Elsevier B.V. All rights reserved.

引用

页码：443 / 450

页数：8

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