mTOR Signaling in Epileptogenesis: Too Much of a Good Thing?

被引:14
作者
Cao, Ruifeng [1 ,2 ]
Li, Aiqing [1 ]
Cho, Hee-Yeon [1 ,3 ]
机构
[1] Ohio State Univ, Dept Neurosci, Columbus, OH 43210 USA
[2] Ohio State Univ, Neurosci Grad Studies Program, Columbus, OH 43210 USA
[3] Ohio State Univ, Dev Biol Grad Program, Columbus, OH 43210 USA
关键词
TEMPORAL-LOBE EPILEPSY; MAMMALIAN TARGET; PATHWAY; INHIBITION; DISEASE; MODEL;
D O I
10.1523/JNEUROSCI.3486-09.2009
中图分类号
Q189 [神经科学];
学科分类号
071006 ;
摘要
引用
收藏
页码:12372 / 12373
页数:2
相关论文
共 11 条
[1]  
Androutsellis-Theotokis A, 2006, NATURE, V442, P823, DOI 10.1038/nature04940
[2]   Inhibition of the Mammalian Target of Rapamycin Signaling Pathway Suppresses Dentate Granule Cell Axon Sprouting in a Rodent Model of Temporal Lobe Epilepsy [J].
Buckmaster, Paul S. ;
Ingram, Elizabeth A. ;
Wen, Xiling .
JOURNAL OF NEUROSCIENCE, 2009, 29 (25) :8259-8269
[3]  
Castedo M, 2002, CELL DEATH DIFFER, V9, P99, DOI 10.1038/sj/cdd/4400978
[4]   Autophagy in neuroprotection and neurodegeneration: a question of balance [J].
Cherra, Salvatore J., III ;
Chu, Charleen T. .
FUTURE NEUROLOGY, 2008, 3 (03) :309-323
[5]   Translational Control of Long-Lasting Synaptic Plasticity and Memory [J].
Costa-Mattioli, Mauro ;
Sossin, Wayne S. ;
Klann, Eric ;
Sonenberg, Nahum .
NEURON, 2009, 61 (01) :10-26
[6]   Dysregulation of the TSC-mTOR pathway in human disease [J].
Inoki, K ;
Corradetti, MN ;
Guan, KL .
NATURE GENETICS, 2005, 37 (01) :19-24
[7]   Inhibition of mTOR induces autophagy and reduces toxicity of polyglutamine expansions in fly and mouse models of Huntington disease [J].
Ravikumar, B ;
Vacher, C ;
Berger, Z ;
Davies, JE ;
Luo, SQ ;
Oroz, LG ;
Scaravilli, F ;
Easton, DF ;
Duden, R ;
O'Kane, CJ ;
Rubinsztein, DC .
NATURE GENETICS, 2004, 36 (06) :585-595
[8]   Binding of rapamycin analogs to channels and FKBP52 contributes their neuroprotective activities [J].
Ruan, Benfang ;
Pong, Kevin ;
Jow, Flora ;
Bowlby, Mark ;
Crozier, Robert A. ;
Liu, Danni ;
Liang, Shi ;
Chen, Yi ;
Mercado, Mary Lynn ;
Feng, Xidong ;
Bennettt, Frann ;
von Schack, David ;
McDonald, Leonard ;
Zaleska, Margaret M. ;
Wood, Andrew ;
Reinhart, Peter H. ;
Magolda, Ronald L. ;
Skotnicki, Jerauld ;
Pangalos, Menelas N. ;
Koehn, Frank E. ;
Carter, Guy T. ;
Abou-Gharbia, Magid ;
Graziani, Edmund I. .
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 2008, 105 (01) :33-38
[9]   Kainic acid induces early and transient autophagic stress in mouse hippocampus [J].
Shacka, John J. ;
Lu, Jun ;
Xie, Zuo-Lei ;
Uchiyama, Yasuo ;
Roth, Kevin A. ;
Zhang, Jianhua .
NEUROSCIENCE LETTERS, 2007, 414 (01) :57-60
[10]   Akt-1 expression level regulates CNS precursors [J].
Sinor, AD ;
Lillien, L .
JOURNAL OF NEUROSCIENCE, 2004, 24 (39) :8531-8541