Iron-Catalyzed Cross-Coupling of Alkyl Sulfonates with Arylzinc Reagents

被引：76

作者：

Ito, Shingo

Fujiwara, Yu-ichi

Nakamura, Eiichi

Nakamura, Masaharu ^{[1
]}

机构：

[1] Kyoto Univ, IRCELS, Inst Chem Res, Grad Sch Engn, Kyoto 6110011, Japan

来源：

ORGANIC LETTERS | 2009年 / 11卷 / 19期

关键词：

GRIGNARD-REAGENTS; FUNCTIONALIZED ARYLMAGNESIUM; LITHIUM DIORGANOCUPRATES(I); HALIDES; TOSYLATES; NICKEL; STEREOCHEMISTRY; ALKENYLATION; ARYLATION; BROMIDES;

D O I：

10.1021/ol901610a

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

Iron-catalyzed cross-coupling reactions of primary and secondary alkyl sulfonates with arylzinc reagents proceed smoothly in the presence of excess TMEDA and a concomitant magnesium salt. The arylzinc reagents are prepared from the corresponding aryllithium or magnesium reagents with ZnI2. The in situ formation of alkyl Iodides and consecutive rapid cross-coupling avoids discrete preparation of the unstable secondary alkyl halides and also achieves high product selectivity.

引用

页码：4306 / 4309

页数：4

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