Iron-catalyzed alkylations of aromatic Grignard reagents

被引：274

作者：

Cahiez, Gerard ^{[1
]}

Habiak, Vanessa ^{[1
]}

Duplais, Christophe ^{[1
]}

Moyeux, Alban ^{[1
]}

机构：

[1] UCP, UMR 8123, CNRS, ESCOM,Lab Synth Organ Select & Chim Organomet, F-95092 Cergy Pontoise, France

来源：

ANGEWANDTE CHEMIE-INTERNATIONAL EDITION | 2007年 / 46卷 / 23期

关键词：

cross-coupling; Grignard reagents; homogeneous catalysis; iron; sustainable chemistry;

D O I：

10.1002/anie.200700742

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

(Chemical Equation Presented) Any old iron: Two efficient iron-catalyzed cross-coupling reactions between aryl Grignard reagents and alkyl bromides were developed that are suitable for large-scale applications. The first procedure uses iron acetylacetonate and involves a cooperative effect between the two ligands N,N,N′,N′-tetramethylethylenediamine (TMEDA) and hexamethylenetetraamine (HMTA), while the second procedure uses [(FeCl 3)2(tmeda)3] as catalyst. 2007 Wiley-VCH Verlag GmbH & Co. KGaA.

引用

页码：4364 / 4366

页数：3

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