Asymmetric desymmetrization of a σ-symmetric erythritol derivative using C2-symmetric bis-sulfoxide:: a total synthesis of (+)-aspicilin

被引：19

作者：

Maezaki, N ^{[1
]}

Li, YX ^{[1
]}

Ohkubo, K ^{[1
]}

Goda, S ^{[1
]}

Iwata, C ^{[1
]}

Tanaka, T ^{[1
]}

机构：

[1] Osaka Univ, Grad Sch Pharmaceut Sci, Suita, Osaka 5650871, Japan

来源：

TETRAHEDRON | 2000年 / 56卷 / 26期

关键词：

asymmetric synthesis; sulfoxides; natural products; macrolides;

D O I：

10.1016/S0040-4020(00)00337-9

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

A total synthesis of (+)-aspicilin 1 was accomplished via an asymmetric desymmetrization of a meso-erythritol derivative using a C-2-symmetric bis-sulfoxide and a chelation-controlled Grignard reaction as the key steps. (C) 2000 Elsevier Science Ltd. All rights reserved.

引用

页码：4405 / 4413

页数：9

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