Role of genetic polymorphisms in tumour angiogenesis

被引：67

作者：

Balasubramanian, SP

Brown, NJ

Reed, MWR ^{[1
]}

机构：

[1] Univ Sheffield, Acad Unit Surg Oncol, Sheffield S10 2JF, S Yorkshire, England

[2] Univ Sheffield, Acad Unit Surg, Sheffield S10 2JF, S Yorkshire, England

来源：

BRITISH JOURNAL OF CANCER | 2002年 / 87卷 / 10期

关键词：

tumour angiogenesis; genetic polymorphism(s);

D O I：

10.1038/sj.bjc.6600625

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

Angiogenesis plays a crucial role in the development, growth and spread of solid tumours. Pro- and anti-angiogenic factors are abnormally expressed in tumours, influencing tumour angiogenesis, growth and progression. Polymorphisms in genes encoding angiogenic factors or their receptors may alter protein expression and/or activity. This article reviews the literature to determine the possible role of angiogenesis-related polymorphisms in cancer. Further research studies in this potentially crucial area of tumour biology are proposed. (C) 2002 Cancer Research UK.

引用

页码：1057 / 1065

页数：9

共 107 条

[71] A common 936 C/T mutation in the gene for vascular endothelial growth factor is associated with vascular endothelial growth factor plasma levels [J].