Expression of three glutamate transporter subtype mRNAs in human brain regions and peripheral tissues

被引：40

作者：

Nakayama, T

Kawakami, H

Tanaka, K

Nakamura, S

机构：

[1] HIROSHIMA UNIV,SCH MED,DEPT INTERNAL MED 3,MINAMI KU,HIROSHIMA 734,JAPAN

[2] NATL INST NEUROSCI,NCNP,DEPT DEGENERAT NEUROL DIS,KODAIRA,TOKYO 187,JAPAN

来源：

MOLECULAR BRAIN RESEARCH | 1996年 / 36卷 / 01期

关键词：

glutamate metabolism; Northern blot analysis; neurotransmission; neurodegenerative disease; hGLT-1; hGluT-1; hEAAC1;

D O I：

10.1016/0169-328X(95)00297-6

中图分类号：

Q189 [神经科学];

学科分类号：

071006 ;

摘要：

We compared the expression of mRNAs for three human glutamate transporter subtypes in human central nervous system (CNS) and other organs by Northern blot analysis. hGLT-1 and hGluT-1 mRNAs were most abundantly expressed in the brain, while hEAAC1 mRNA expression (3.8 kb and 2.4 kb) was strongest in peripheral organs. All subtype mRNAs were expressed throughout the CNS with hGLT-1 predominant in frontal lobe, striatum and limbic areas, and hGluT-1 predominant in cerebellum.

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收藏

页码：189 / 192

页数：4

相关论文

共 18 条

[1] IMAGING PLATE ILLUMINATES MANY FIELDS [J].

AMEMIYA, Y ;

MIYAHARA, J .

NATURE, 1988, 336 (6194) :89-90

[2] GLUTAMATE NEUROTOXICITY AND DISEASES OF THE NERVOUS-SYSTEM [J].

CHOI, DW .

NEURON, 1988, 1 (08) :623-634

[3] A TECHNIQUE FOR RADIOLABELING DNA RESTRICTION ENDONUCLEASE FRAGMENTS TO HIGH SPECIFIC ACTIVITY [J].

FEINBERG, AP ;

VOGELSTEIN, B .

ANALYTICAL BIOCHEMISTRY, 1983, 132 (01) :6-13

[4] INDUCTION OF THROMBOXANE SYNTHASE AND PROSTAGLANDIN ENDOPEROXIDE SYNTHASE MESSENGER-RNAS IN HUMAN ERYTHROLEUKEMIA-CELLS BY PHORBOL ESTER [J].

IHARA, H ;

YOKOYAMA, C ;

MIYATA, A ;

KOSAKA, T ;

NUSING, R ;

ULLRICH, V ;

TANABE, T .

FEBS LETTERS, 1992, 306 (2-3) :161-164

[5] PRIMARY STRUCTURE AND FUNCTIONAL-CHARACTERIZATION OF A HIGH-AFFINITY GLUTAMATE TRANSPORTER [J].

KANAI, Y ;

HEDIGER, MA .

NATURE, 1992, 360 (6403) :467-471

[6] CLONING AND EXPRESSION OF A HUMAN GLUTAMATE TRANSPORTER [J].

KAWAKAMI, H ;

TANAKA, K ;

NAKAYAMA, T ;

INOUE, K ;

NAKAMURA, S .

BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS, 1994, 199 (01) :171-176

[7] EXCITATORY AMINO ACID-RELEASING AND CHOLINERGIC NEURONS IN ALZHEIMERS-DISEASE [J].

PALMER, AM ;

PROCTER, AW ;

STRATMANN, GC ;

BOWEN, DM .

NEUROSCIENCE LETTERS, 1986, 66 (02) :199-204

[8] CLONING AND EXPRESSION OF A RAT-BRAIN L-GLUTAMATE TRANSPORTER [J].

PINES, G ;

DANBOLT, NC ;

BJORAS, M ;

ZHANG, YM ;

BENDAHAN, A ;

EIDE, L ;

KOEPSELL, H ;

STORMMATHISEN, J ;

SEEBERG, E ;

KANNER, BI .

NATURE, 1992, 360 (6403) :464-467

[9] LOCALIZATION OF NEURONAL AND GLIAL GLUTAMATE TRANSPORTERS [J].

ROTHSTEIN, JD ;

MARTIN, L ;

LEVEY, AI ;

DYKESHOBERG, M ;

JIN, L ;

WU, D ;

NASH, N ;

KUNCL, RW .

NEURON, 1994, 13 (03) :713-725

[10] DECREASED GLUTAMATE TRANSPORT BY THE BRAIN AND SPINAL-CORD IN AMYOTROPHIC-LATERAL-SCLEROSIS [J].

ROTHSTEIN, JD ;

MARTIN, LJ ;

KUNCL, RW .

NEW ENGLAND JOURNAL OF MEDICINE, 1992, 326 (22) :1464-1468