Temperature, viral genetics, and the transmission of West Nile virus by Culex pipiens mosquitoes

被引:301
作者
Kilpatrick, A. Marm [1 ,2 ]
Meola, Mark A. [3 ]
Moudy, Robin M. [3 ]
Kramer, Laura D. [3 ,4 ]
机构
[1] Consortium Conservat Med, New York, NY USA
[2] Univ Calif Santa Cruz, Dept Ecol & Evolutionary Biol, Santa Cruz, CA 95064 USA
[3] New York State Dept Hlth, Wadsworth Ctr, Slingerlands, NY USA
[4] SUNY Albany, Dept Biomed Sci, Sch Publ Hlth, Albany, NY USA
基金
美国国家卫生研究院; 美国国家科学基金会;
关键词
D O I
10.1371/journal.ppat.1000092
中图分类号
Q93 [微生物学];
学科分类号
071005 ; 100705 ;
摘要
The distribution and intensity of transmission of vector-borne pathogens can be strongly influenced by the competence of vectors. Vector competence, in turn, can be influenced by temperature and viral genetics. West Nile virus (WNV) was introduced into the United States of America in 1999 and subsequently spread throughout much of the Americas. Previously, we have shown that a novel genotype of WNV, WN02, first detected in 2001, spread across the US and was more efficient than the introduced genotype, NY99, at infecting, disseminating, and being transmitted by Culex mosquitoes. In the current study, we determined the relationship between temperature and time since feeding on the probability of transmitting each genotype of WNV. We found that the advantage of the WN02 genotype increases with the product of time and temperature. Thus, warmer temperatures would have facilitated the invasion of the WN02 genotype. In addition, we found that transmission of WNV accelerated sharply with increasing temperature, T, (best fit by a function of T(4)) showing that traditional degree-day models underestimate the impact of temperature on WNV transmission. This laboratory study suggests that both viral evolution and temperature help shape the distribution and intensity of transmission of WNV, and provides a model for predicting the impact of temperature and global warming on WNV transmission.
引用
收藏
页数:7
相关论文
共 60 条
[21]  
HURLBUT HS, 1973, J MED ENTOMOL, V10, P1, DOI 10.1093/jmedent/10.1.1
[22]   Potential changes in the distribution of dengue transmission under climate warming [J].
Jetten, TH ;
Focks, DA .
AMERICAN JOURNAL OF TROPICAL MEDICINE AND HYGIENE, 1997, 57 (03) :285-297
[23]   Characterization of a small plaque variant of West Nile virus isolated in New York in 2000 [J].
Jia, Yongqing ;
Moudy, Robin M. ;
Dupuis, Alan P., II ;
Ngo, Kiet A. ;
Maffei, Joseph G. ;
Jerzak, Greta V. S. ;
Franke, Mary A. ;
Kauffman, Elizabeth B. ;
Kramer, Laura D. .
VIROLOGY, 2007, 367 (02) :339-347
[24]   Enhancement or modulation of the vector competence of ochlerotatus vigilax (Diptera: Culicidae) for Ross River virus by temperature [J].
Kay, BH ;
Jennings, CD .
JOURNAL OF MEDICAL ENTOMOLOGY, 2002, 39 (01) :99-105
[25]   REARING TEMPERATURE INFLUENCES FLAVIVIRUS VECTOR COMPETENCE OF MOSQUITOS [J].
KAY, BH ;
FANNING, ID ;
MOTTRAM, P .
MEDICAL AND VETERINARY ENTOMOLOGY, 1989, 3 (04) :415-422
[26]  
Kilpatrick AM, 2007, AUK, V124, P1121, DOI 10.1642/0004-8038(2007)124[1121:EOWNVT]2.0.CO
[27]  
2
[28]   Genetic influences on mosquito feeding behavior and the emergence of zoonotic pathogens [J].
Kilpatrick, A. Marm ;
Kramer, Laura D. ;
Jones, Matthew J. ;
Marra, Peter P. ;
Daszak, Peter ;
Fonseca, Dina M. .
AMERICAN JOURNAL OF TROPICAL MEDICINE AND HYGIENE, 2007, 77 (04) :667-671
[29]   Host heterogeneity dominates West Nile virus transmission [J].
Kilpatrick, A. Marm ;
Daszak, Peter ;
Jones, Matthew J. ;
Marra, Peter P. ;
Kramer, Laura D. .
PROCEEDINGS OF THE ROYAL SOCIETY B-BIOLOGICAL SCIENCES, 2006, 273 (1599) :2327-2333
[30]   West Nile virus epidemics in North America are driven by shifts in mosquito feeding behavior [J].
Kilpatrick, AM ;
Kramer, LD ;
Jones, MJ ;
Marra, PP ;
Daszak, P .
PLOS BIOLOGY, 2006, 4 (04) :606-610