Natural antimycobacterial metabolites: current status

被引：150

作者：

Okunade, AL ^{[1
]}

Elvin-Lewis, MPF ^{[1
]}

Lewis, WH ^{[1
]}

机构：

[1] Washington Univ, Dept Biol, St Louis, MO 63130 USA

来源：

PHYTOCHEMISTRY | 2004年 / 65卷 / 08期

关键词：

review; antimycobacterial metabolites; plants; fungi; marine organisms;

D O I：

10.1016/j.phytochem.2004.02.013

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Over the years the introduction of very effective drugs has revolutionized the treatment of tuberculosis. In recent years, however, emerging multiple drug resistance has become a major threat and thus calls for an urgent search for new and effective treatments for this deadly disease. This review is complementary to earlier reviews and covers more recent reports of naturally occurring compounds, and in some cases synthetic analogs, largely from plants, fungi and marine organisms that demonstrate significant activity in the in vitro bioassays against Mycobacterium tuberculosis, and other mycobacterial species. Included also are traditional medicinal uses of specific plants when utilized to treat tuberculosis and other pulmonary diseases. (C) 2004 Elsevier Ltd. All rights reserved.

引用

页码：1017 / 1032

页数：16

共 81 条

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