A new antimycobacterial, 3β-acetoxy-15α,22-dihydroxyhopane, from the insect pathogenic fungus Aschersonia tubulata

被引：37

作者：

Boonphong, S

Kittakoop, P ^{[1
]}

Isaka, M

Palittapongarnpim, P

Jaturapat, A

Danwisetkanjana, K

Tanticharoen, M

Thebtaranonth, Y

机构：

[1] Naresuan Univ, Fac Sci, Dept Chem, Phitsanulok, Thailand

[2] Natl Sci & Technol Dev Agcy, Natl Ctr Genet Engn & Biotechnol, Bangkok, Thailand

[3] Mahidol Univ, Fac Sci, Dept Chem, Bangkok 10700, Thailand

来源：

PLANTA MEDICA | 2001年 / 67卷 / 03期

关键词：

D O I：

10.1055/s-2001-11997

中图分类号：

Q94 [植物学];

学科分类号：

071001 ;

摘要：

Bioassay-guided fractionation of the cell extract of the insect pathogenic fungus Aschersonia tubulata BCC 1785 led to the isolation of dustanin (1), 3 beta ,15 alpha ,22-trihydroxyhopane (3), 5 alpha ,8 alpha -epidioxy-24(R)-methylcholesta-6,22-diene-3 beta -ol (6), together with the new 3 beta -acetoxy-15 alpha ,22-dihydroxyhopane (4). Chemical structures of these compounds were elucidated by spectral analyses as well as chemical transformation. Compounds 1 and 4 exhibited antimycobacterial activity with the minimum inhibitory concentration (MIC) of 12.5 mug/ml.

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页码：279 / 281

页数：3

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