The complexity of nitrogen metabolism and nitrogen-regulated gene expression in plant pathogenic fungi

被引:58
作者
Bolton, Melvin D. [2 ]
Thomma, Bart P. H. J. [1 ]
机构
[1] Univ Wageningen & Res Ctr, Phytopathol Lab, NL-6709 PD Wageningen, Netherlands
[2] ARS, USDA, No Crop Sci Lab, Fargo, ND 58105 USA
关键词
Nitrogen; Fungal; Effector; Cladosporium;
D O I
10.1016/j.pmpp.2008.07.001
中图分类号
Q94 [植物学];
学科分类号
071001 ;
摘要
Plant pathogens secrete effector molecules that contribute to the establishment of disease in their plant hosts. The identification of cellular cues that regulate effector gene expression is an important aspect of understanding the infection process. Nutritional status in the cell has been postulated to be a cue for effector gene expression. Several studies have shown the induction of the same effector genes during growth under nitrogen-starved conditions in vitro as during growth in planta, suggesting that a nitrogen-poor environment exists during colonization. As a consequence, it has been proposed that growth in nitrogen-starved media mimics the environment that a pathogen encounters during growth in planta. Although this relationship has been implied in several studies, there is little known regarding available nitrogen during colonization for fungal pathogens. This review focuses on the effect of nitrogen starvation on fungal effector gene expression and examines the role of fungal nitrogen regulatory genes to help gain an understanding of whether nitrogen availability within the host is an important factor in disease development. (C) 2008 Elsevier Ltd. All rights reserved.
引用
收藏
页码:104 / 110
页数:7
相关论文
共 92 条
[1]   Characterization of the Aspergillus nidulans nmrA gene involved in nitrogen metabolite repression [J].
Andrianopoulos, A ;
Kourambas, S ;
Sharp, JA ;
Davis, MA ;
Hynes, MJ .
JOURNAL OF BACTERIOLOGY, 1998, 180 (07) :1973-1977
[2]   Sensing the environment: lessons from fungi [J].
Bahn, Yong-Sun ;
Xue, Chaoyang ;
Idnurm, Alexander ;
Rutherford, Julian C. ;
Heitman, Joseph ;
Cardenas, Maria E. .
NATURE REVIEWS MICROBIOLOGY, 2007, 5 (01) :57-69
[3]   The pathogen-host interactions database (PHI-base) provides insights into generic and novel themes of pathogenicity [J].
Baldwin, Thomas K. ;
Winnenburg, Rainer ;
Urban, Martin ;
Rawlings, Chris ;
Koehler, Jacob ;
Hammond-Kosack, Kim E. .
MOLECULAR PLANT-MICROBE INTERACTIONS, 2006, 19 (12) :1451-1462
[4]   A maize-specifically expressed gene cluster in Ustilago maydis [J].
Basse, CW ;
Kolb, S ;
Kahmann, R .
MOLECULAR MICROBIOLOGY, 2002, 43 (01) :75-93
[5]   Characterization of a Ustilago maydis gene specifically induced during the biotrophic phase:: Evidence for negative as well as positive regulation [J].
Basse, CW ;
Stumpferl, S ;
Kahmann, R .
MOLECULAR AND CELLULAR BIOLOGY, 2000, 20 (01) :329-339
[6]   Sclerotinia sclerotiorum (Lib.) de Bary:: biology and molecular traits of a cosmopolitan pathogen [J].
Bolton, MD ;
Thomma, BPHJ ;
Nelson, BD .
MOLECULAR PLANT PATHOLOGY, 2006, 7 (01) :1-16
[7]   Wheat leaf rust caused by Puccinia triticina [J].
Bolton, Melvin D. ;
Kolmer, James A. ;
Garvin, David F. .
MOLECULAR PLANT PATHOLOGY, 2008, 9 (05) :563-575
[8]   The novel Cladosporium fulvum lysin motif effector Ecp6 is a virulence factor with orthologues in other fungal species [J].
Bolton, Melvin D. ;
van Esse, H. Peter ;
Vossen, Jack H. ;
de Jonge, Ronnie ;
Stergiopoulos, Ioannis ;
Stulemeijer, Iris J. E. ;
van den Berg, Grardy C. M. ;
Borras-Hidalgo, Orlando ;
Dekker, Henk L. ;
de Koster, Chris G. ;
de Wit, Pierre J. G. M. ;
Joosten, Matthieu H. A. J. ;
Thomma, Bart P. H. J. .
MOLECULAR MICROBIOLOGY, 2008, 69 (01) :119-136
[9]   Differential protein expression in Colletotrichum acutatum:: changes associated with reactive oxygen species and nitrogen starvation implicated in pathogenicity on strawberry [J].
Brown, Sigal Horowitz ;
Yarden, Oded ;
Gollop, Natan ;
Chen, Songbi ;
Zveibil, Aida ;
Belausov, Eduard ;
Freeman, Stanley .
MOLECULAR PLANT PATHOLOGY, 2008, 9 (02) :171-190
[10]   NIRA, THE PATHWAY-SPECIFIC REGULATORY GENE OF NITRATE ASSIMILATION IN ASPERGILLUS-NIDULANS, ENCODES A PUTATIVE GAL4-TYPE ZINC FINGER PROTEIN AND CONTAINS 4 INTRONS IN HIGHLY CONSERVED REGIONS [J].
BURGER, G ;
STRAUSS, J ;
SCAZZOCCHIO, C ;
LANG, BF .
MOLECULAR AND CELLULAR BIOLOGY, 1991, 11 (11) :5746-5755