Water-Soluble Iron Oxide Nanocubes with High Values of Specific Absorption Rate for Cancer Cell Hyperthermia Treatment

被引：604

作者：

Guardia, Pablo ^{[1
]}

Di Corato, Riccardo ^{[1
,2
]}

Lartigue, Lenaic ^{[3
,4
]}

Wilhelm, Claire ^{[3
,4
]}

Espinosa, Ana ^{[5
]}

Garcia-Hernandez, Mar ^{[5
]}

Gazeau, Florence ^{[3
,4
]}

Manna, Liberato ^{[1
]}

Pellegrino, Teresa ^{[1
,2
]}

机构：

[1] Ist Italiano Tecnol, I-16163 Genoa, Italy

[2] Natl Nanotechnol Lab CNR NANO, I-73100 Lecce, Italy

[3] Univ Paris Diderot, F-75205 Paris 13, France

[4] CNRS, UMR 7057, Lab Matiere & Syst Complexes MSC, F-75205 Paris 13, France

[5] CSIC, Inst Ciencia Mat Madrid, Madrid 28049, Spain

来源：

ACS NANO | 2012年 / 6卷 / 04期

关键词：

hyperthermia treatment; specific absorption rate; SAR values; iron oxide nanoparticles; magnetic nanoparticles; biomedical applications; magnetosome-like nanoparticles; MAGNETIC PARTICLE HYPERTHERMIA; HYDROPHOBIC NANOCRYSTALS; BACTERIAL MAGNETOSOMES; NANOPARTICLE DESIGN; LIMITATIONS; MEDIATORS; FLUID;

D O I：

10.1021/nn2048137

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

Iron oxide nanoaystals (IONCs) are appealing heat mediator nanoprobes in magnetic-mediated hyperthermia for cancer treatment Here, specific absorption rate (SAR) values are reported for cube-shaped water-soluble IONCs prepared by a one-pot synthesis approach in a size range between 13 and 40 nm. The SAR values were determined as a function of frequency and magnetic field applied, also spanning technical conditions which are considered biomedically safe for patients. Among the different sizes tested, IONCs with an average diameter of 19 +/- 3 nm had significant SAR values in clinical conditions and reached SAR values up to 2452 W/g(Fe) at 520 kHz and 29 kAm(-1), which is one of the highest values so far reported for IONCs. In vitro trials carried out on KB cancer cells treated with IONCs of 19 nm have shown efficient hyperthermia performance, With cell mortality of about 50% recorded when an equilibrium temperature of 43 degrees C was reached after 1 h of treatment.

引用

页码：3080 / 3091

页数：12

共 57 条

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