Two-carbon ring expansion of β-lactams via N(1)-C(4) cleavage reactions

被引：12

作者：

Cabell, LA ^{[1
]}

McMurray, JS ^{[1
]}

机构：

[1] Univ Texas, MD Anderson Canc Ctr, Dept Neurooncol, Houston, TX 77030 USA

来源：

TETRAHEDRON LETTERS | 2002年 / 43卷 / 14期

关键词：

D O I：

10.1016/S0040-4039(02)00318-0

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

The base-catalyzed ring opening of 4-(4'-hydroxyphenyl)-azetidine-2-ones with potassium tert-butoxide in the presence of tert-butyl methyl malonate gave 1,3,4,5-substituted glutarimides in a simple and efficient manner. The glutarimides were formed stereo selectively depending on the size or the 3-substituent of the beta-lactam. (C) 2002 Elsevier Science Ltd. All rights reserved.

引用

页码：2491 / 2493

页数：3

共 8 条

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