miRTarBase update 2014: an information resource for experimentally validated miRNA-target interactions

被引：587

作者：

Hsu, Sheng-Da ^{[1
]}

Tseng, Yu-Ting ^{[2
,3
]}

Shrestha, Sirjana ^{[4
]}

Lin, Yu-Ling ^{[4
,5
]}

Khaleel, Anas ^{[6
]}

Chou, Chih-Hung ^{[1
]}

Chu, Chao-Fang ^{[1
]}

Huang, Hsi-Yuan ^{[1
,5
]}

Lin, Ching-Min ^{[7
]}

Ho, Shu-Yi ^{[4
]}

Jian, Ting-Yan ^{[7
]}

Lin, Feng-Mao ^{[1
]}

Chang, Tzu-Hao ^{[8
]}

Weng, Shun-Long ^{[1
,9
,10
,11
]}

Liao, Kuang-Wen ^{[4
,7
]}

Liao, I-En ^{[3
]}

Liu, Chun-Chi ^{[2
]}

Huang, Hsien-Da ^{[1
,4
,5
,12
]}

机构：

[1] Natl Chiao Tung Univ, Inst Bioinformat & Syst Biol, Hsinchu 300, Taiwan

[2] Natl Chung Hsing Univ, Inst Genom & Bioinformat, Taichung 402, Taiwan

[3] Natl Chung Hsing Univ, Dept Comp Sci & Engn, Taichung 402, Taiwan

[4] Natl Chiao Tung Univ, Dept Biol Sci & Technol, Hsinchu 300, Taiwan

[5] Natl Chiao Tung Univ, Mol Bioinformat Ctr, Hsinchu 300, Taiwan

[6] Taipei Med Univ, Grad Dept Clin Pharm, Taipei 110, Taiwan

[7] Natl Chiao Tung Univ, Inst Mol Med & Bioengn, Hsinchu 300, Taiwan

[8] Taipei Med Univ, Grad Inst Biomed Informat, Taipei 110, Taiwan

[9] Hsinchu Mackay Mem Hosp, Dept Obstet & Gynecol, Hsinchu 300, Taiwan

[10] Nursing & Management Coll, Mackay Med, Taipei 112, Taiwan

[11] Mackay Med Coll, Dept Med, New Taipei City 252, Taiwan

[12] Kaohsiung Med Univ, Dept Biomed Sci & Environm Biol, Kaohsiung 807, Taiwan

来源：

NUCLEIC ACIDS RESEARCH | 2014年 / 42卷 / D1期

关键词：

TRANSCRIPTOME-WIDE IDENTIFICATION; INTEGRATIVE ANALYSIS; PARALLEL ANALYSIS; MICRORNA TARGETS; RNA INTERACTIONS; MESSENGER-RNAS; EXPRESSION; DATABASE; OVEREXPRESSION; PREDICTION;

D O I：

10.1093/nar/gkt1266

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

070307 [化学生物学]; 071010 [生物化学与分子生物学];

摘要：

MicroRNAs (miRNAs) are small non-coding RNA molecules capable of negatively regulating gene expression to control many cellular mechanisms. The miRTarBase database (http://mirtarbase.mbc.nctu.edu.tw/) provides the most current and comprehensive information of experimentally validated miRNA-target interactions. The database was launched in 2010 with data sources for >100 published studies in the identification of miRNA targets, molecular networks of miRNA targets and systems biology, and the current release (2013, version 4) includes significant expansions and enhancements over the initial release (2010, version 1). This article reports the current status of and recent improvements to the database, including (i) a 14-fold increase to miRNA-target interaction entries, (ii) a miRNA-target network, (iii) expression profile of miRNA and its target gene, (iv) miRNA target-associated diseases and (v) additional utilities including an upgrade reminder and an error reporting/user feedback system.

引用

页码：D78 / D85

页数：8

共 69 条

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