Additive effects of serotonin transporter and tryptophan hydroxylase-2 gene variation on neural correlates of affective processing

被引:68
作者
Canli, Turhan [1 ,2 ]
Congdon, Eliza [1 ]
Constable, R. Todd [3 ]
Lesch, Klaus Peter [4 ]
机构
[1] SUNY Stony Brook, Dept Psychol, Stony Brook, NY 11794 USA
[2] SUNY Stony Brook, Grad Program Genet, Stony Brook, NY 11794 USA
[3] Yale Univ, MRRC, New Haven, CT 06520 USA
[4] Univ Wurzburg, Dept Psychiat & Psychotherapy, Wurzburg, Germany
基金
美国国家科学基金会;
关键词
serotonin transporter; tryptophan hydroxylase-2; polymorphism; emotion; affect; striatum; putamen; amygdala; genetics; imaging; fMRI; functional magnetic resonance imaging;
D O I
10.1016/j.biopsycho.2008.01.004
中图分类号
B84 [心理学];
学科分类号
04 ; 0402 ;
摘要
Individual differences in brain response to emotional stimuli have previously been associated with gene variations within the serotonin transporter (5-HTT) and tryptophan hydroxylase-2 (TPH2) genes. We recently reported that these two genes exhibit an additive effect, based on recordings of event-related potentials (ERPs) from individuals viewing emotional scenes. The current study was designed to replicate and extent this initial report in an independent study sample, and use functional magnetic resonance imaging (fMRI) to identify specific neural loci that may mediate the 5-HTT-TPH2 additive effect. Furthermore, we sought to obtain convergent evidence for a gene-gene additive effect by collecting fMRI data from the same individuals engaged in two different cognitive-affective tasks, using emotional and neutral facial expressions and word stimuli. We found evidence for an additive effect of 5-HTT-TPH2 genotype, which was most robust in the putamen, a region rich in both 5-HTT and TPH2 protein, but was also observed in the amygdala at a less stringent threshold, and in other cortical regions. The additive effect was more robust effect for visuospatial than for verbal stimuli, and more robust for negatively than for positively valenced stimuli. These findings confirm and extend the additive effect of two critical genes in the serotonergic regulation of neural processing of affective stimuli, and identify the striatum as a critical site where is gene-gene regulation takes place. (C) 2008 Elsevier B.V. All rights reserved.
引用
收藏
页码:118 / 125
页数:8
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