HuPho: the human phosphatase portal

被引：49

作者：

Liberti, Susanna ^{[1
]}

Sacco, Francesca ^{[1
]}

Calderone, Alberto ^{[1
]}

Perfetto, Livia ^{[1
]}

Iannuccelli, Marta ^{[1
]}

Panni, Simona ^{[1
,2
]}

Santonico, Elena ^{[1
]}

Palma, Anita ^{[1
]}

Nardozza, Aurelio P. ^{[1
]}

Castagnoli, Luisa ^{[1
]}

Cesareni, Gianni ^{[1
,3
]}

机构：

[1] Univ Roma Tor Vergata, Dept Biol, I-00173 Rome, Italy

[2] Univ Calabria, Dept Cell Biol, I-87036 Arcavacata Di Rende, Italy

[3] Fdn Santa Lucia, Res Inst, Rome, Italy

来源：

FEBS JOURNAL | 2013年 / 280卷 / 02期

关键词：

database; phosphatase substrates; phosphatases; phosphorylation; protein interaction; PROTEIN-TYROSINE PHOSPHATASES; MOLECULAR INTERACTION DATABASE; SERINE/THREONINE PHOSPHATASES; HUMAN GENOME; EYES ABSENT; MAP KINASE; UPDATE; DISEASE; DEPHOSPHORYLATION; KNOWLEDGEBASE;

D O I：

10.1111/j.1742-4658.2012.08712.x

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Phosphatases and kinases contribute to the regulation of protein phosphorylation homeostasis in the cell. Phosphorylation is a key post-translational modification underlying the regulation of many cellular processes. Thus, a comprehensive picture of phosphatase function and the identification of their target substrates would aid a systematic approach to a mechanistic description of cell signalling. Here we present a website designed to facilitate the retrieval of information about human protein phosphatases. To this end we developed a search engine to recover and integrate information annotated in several publicly available web resources. In addition we present a text-mining-assisted annotation effort aimed at extracting phosphatase related data reported in the scientific literature. The HuPho (human phosphatases) website can be accessed at http://hupho.uniroma2.it.

引用

页码：379 / 387

页数：9

共 47 条

[1] Protein tyrosine phosphatases in the human genome [J].

Alonso, A ;

Sasin, J ;

Bottini, N ;

Friedberg, I ;

Osterman, A ;

Godzik, A ;

Hunter, T ;

Dixon, J ;

Mustelin, T .

CELL, 2004, 117 (06) :699-711

[2] Computational analysis of protein tyrosine phosphatases: practical guide to bioinformatics and data resources [J].

Andersen, JN ;

Del Vecchio, RL ;

Kannan, N ;

Gergel, J ;

Neuwald, AF ;

Tonks, NK .

METHODS, 2005, 35 (01) :90-114

[3] A genomic perspective on protein tyrosine phosphatases: gene structure, pseudogenes, and genetic disease linkage [J].

Andersen, JN ;

Jansen, PG ;

Echwald, SM ;

Mortensen, OH ;

Fukada, T ;

Del Vecchio, R ;

Tonks, NK ;

Moller, NPH .

FASEB JOURNAL, 2004, 18 (01) :8-30

[4] PROTEIN-TYROSINE PHOSPHATASES TAKE-OFF [J].

BARFORD, D ;

JIA, ZC ;

TONKS, NK .

NATURE STRUCTURAL BIOLOGY, 1995, 2 (12) :1043-1053

[5] Large-Scale Structural Analysis of the Classical Human Protein Tyrosine Phosphatome [J].

Barr, Alastair J. ;

Ugochukwu, Emilie ;

Lee, Wen Hwa ;

King, Oliver N. F. ;

Filippakopoulos, Panagis ;

Alfano, Ivan ;

Savitsky, Pavel ;

Burgess-Brown, Nicola A. ;

Mueller, Susanne ;

Knapp, Stefan .

CELL, 2009, 136 (02) :352-363

[6] The protein phosphatase 2C (PP2C) superfamily: Detection of bacterial homologues [J].

Bork, P ;

Brown, NP ;

Hegyi, H ;

Schultz, J .

PROTEIN SCIENCE, 1996, 5 (07) :1421-1425

[7]

Cohen PTW, 2004, TOP CURR GENET, V5, P1

[8]

Deshpande N, 2005, NUCLEIC ACIDS RES, V33, pD233

[9] Protein tyrosine phosphatases, new targets for cancer therapy [J].

Easty, David ;

Gallagher, William ;

Bennett, D. C. .

CURRENT CANCER DRUG TARGETS, 2006, 6 (06) :519-532

[10] Identification of New Substrates of the Protein-tyrosine Phosphatase PTP1B by Bayesian Integration of Proteome Evidence [J].

Ferrari, Emanuela ;

Tinti, Michele ;

Costa, Stefano ;

Corallino, Salvatore ;

Nardozza, Aurelio Pio ;

Chatraryamontri, Andrew ;

Ceol, Arnaud ;

Cesareni, Gianni ;

Castagnoli, Luisa .

JOURNAL OF BIOLOGICAL CHEMISTRY, 2011, 286 (06) :4173-4185

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