HuPho: the human phosphatase portal

被引：49

作者：

Liberti, Susanna ^{[1
]}

Sacco, Francesca ^{[1
]}

Calderone, Alberto ^{[1
]}

Perfetto, Livia ^{[1
]}

Iannuccelli, Marta ^{[1
]}

Panni, Simona ^{[1
,2
]}

Santonico, Elena ^{[1
]}

Palma, Anita ^{[1
]}

Nardozza, Aurelio P. ^{[1
]}

Castagnoli, Luisa ^{[1
]}

Cesareni, Gianni ^{[1
,3
]}

机构：

[1] Univ Roma Tor Vergata, Dept Biol, I-00173 Rome, Italy

[2] Univ Calabria, Dept Cell Biol, I-87036 Arcavacata Di Rende, Italy

[3] Fdn Santa Lucia, Res Inst, Rome, Italy

来源：

FEBS JOURNAL | 2013年 / 280卷 / 02期

关键词：

database; phosphatase substrates; phosphatases; phosphorylation; protein interaction; PROTEIN-TYROSINE PHOSPHATASES; MOLECULAR INTERACTION DATABASE; SERINE/THREONINE PHOSPHATASES; HUMAN GENOME; EYES ABSENT; MAP KINASE; UPDATE; DISEASE; DEPHOSPHORYLATION; KNOWLEDGEBASE;

D O I：

10.1111/j.1742-4658.2012.08712.x

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Phosphatases and kinases contribute to the regulation of protein phosphorylation homeostasis in the cell. Phosphorylation is a key post-translational modification underlying the regulation of many cellular processes. Thus, a comprehensive picture of phosphatase function and the identification of their target substrates would aid a systematic approach to a mechanistic description of cell signalling. Here we present a website designed to facilitate the retrieval of information about human protein phosphatases. To this end we developed a search engine to recover and integrate information annotated in several publicly available web resources. In addition we present a text-mining-assisted annotation effort aimed at extracting phosphatase related data reported in the scientific literature. The HuPho (human phosphatases) website can be accessed at http://hupho.uniroma2.it.

引用

页码：379 / 387

页数：9

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