Adult weight change and risk of colorectal cancer in the European Prospective Investigation into Cancer and Nutrition

被引：64

作者：

Aleksandrova, Krasimira ^{[1
]}

Pischon, Tobias ^{[2
]}

Buijsse, Brian ^{[1
]}

May, Anne M. ^{[3
]}

Peeters, Petra H. ^{[3
,4
]}

Bueno-de-Mesquita, H. Bas ^{[5
,6
]}

Jenab, Mazda ^{[7
]}

Fedirko, Veronika ^{[7
,8
,9
]}

Dahm, Christina C. ^{[10
]}

Siersema, Peter D. ^{[6
]}

Freisling, Heinz ^{[7
]}

Ferrari, Pietro ^{[7
]}

Overvad, Kim ^{[11
]}

Tjonneland, Anne ^{[12
]}

Trichopoulou, Antonia ^{[13
,14
]}

Lagiou, Pagona ^{[14
,15
]}

Naska, Androniki ^{[13
,14
]}

Pala, Valeria ^{[16
]}

Mattiello, Amalia ^{[17
]}

Ohlsson, Bodil ^{[18
]}

Jirstrom, Karin ^{[19
]}

Key, Timothy J. ^{[20
]}

Khaw, Kay-Tee ^{[21
]}

Riboli, Elio ^{[4
]}

Boeing, Heiner ^{[1
]}

机构：

[1] German Inst Human Nutr Potsdam Rehbrucke, Dept Epidemiol, D-14558 Nuthetal, Germany

[2] Max Delbruck Ctr Mol Med, Mol Epidemiol Grp, Berlin, Germany

[3] Univ Med Ctr, Julius Ctr Hlth Sci & Primary Care, Utrecht, Netherlands

[4] Univ London Imperial Coll Sci Technol & Med, Div Epidemiol Publ Hlth & Primary Care, London, England

[5] Natl Inst Publ Hlth & Environm RIVM, Bilthoven, Netherlands

[6] Univ Med Ctr, Dept Gastroenterol & Hepatol, Utrecht, Netherlands

[7] Int Agcy Res Canc IARC WHO, Lyon, France

[8] Emory Univ, Dept Epidemiol, Rollins Sch Publ Hlth, Atlanta, GA 30322 USA

[9] Emory Univ, Winship Canc Inst, Atlanta, GA 30322 USA

[10] Aarhus Univ Hosp, Dept Cardiol, Aalborg, Denmark

[11] Aarhus Univ, Sch Publ Hlth, Dept Epidemiol, Aarhus, Denmark

[12] Danish Canc Soc Res Ctr, Copenhagen, Denmark

[13] Hellen Hlth Fdn, Athens, Greece

[14] Univ Athens, Sch Med, Dept Hyg Epidemiol & Med Stat, WHO Collaborating Ctr Food & Nutr Policies, GR-11527 Athens, Greece

[15] Harvard Univ, Sch Publ Hlth, Dept Epidemiol, Boston, MA 02115 USA

[16] Fdn IRCCS Ist Nazl Tumori, Epidemiol & Prevent Unit, Milan, Italy

[17] Univ Naples Federico II, Dipartimento Med Clin & Chirurg, Naples, Italy

[18] Lund Univ, Dept Clin Sci, Sect Internal Med, Skane Univ Hosp, Malmo, Sweden

[19] Lund Univ, Dept Clin Sci, Div Pathol, Lund, Sweden

[20] Univ Oxford, Canc Epidemiol Unit, Oxford, England

[21] Univ Cambridge, Dept Publ Hlth & Primary Care, Cambridge, England

来源：

EUROPEAN JOURNAL OF CANCER | 2013年 / 49卷 / 16期

基金：

英国医学研究理事会; 英国惠康基金;

关键词：

Body weight change; Colorectal neoplasms; Abdominal obesity; Cancer prevention; BODY-MASS INDEX; COLON-CANCER; RECTAL-CANCER; PROSPECTIVE COHORT; PHYSICAL-ACTIVITY; LIFE-STYLE; OBESITY; WOMEN; SIZE; GAIN;

D O I：

10.1016/j.ejca.2013.06.021

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

Aim: Weight change during adult life may reflect metabolic changes and influence colorectal cancer (CRC) development, but such role is not well established. We aimed to explore the association between adult weight change (from age 20 to 50) and CRC risk. In particular, we investigated differences according to colon and rectal cancer, sex and measures of attained adiposity. Methods: We included 201,696 participants from six participating countries in the European Prospective Investigation into Cancer and Nutrition (1992-2010). During a mean follow-up of 11.2 years 2384 (1194 in men and 1190 in women) incident CRC cases occurred. Cox proportional hazard models adjusted for body mass index at age 20 and lifestyle factors at study recruitment were used to calculate hazard ratios (HRs) and 95% confidence intervals (CIs). Results: After multivariable adjustment, each kg of weight gained annually from age 20 to 50 was associated with a 60% higher risk of colon cancer (95% CI 1.20-2.09), but not rectal cancer (HR 1.13, 95% CI 0.79-1.62, P-interaction = 0.04). The higher risk of colon cancer was restricted to people with high attained waist circumference at age 50 (HR 1.82, 95% CI 1.14-2.91, P-interaction = 0.02). Results were not different in men and women (P-interaction = 0.81). Conclusion(s): Adult weight gain, as reflected by attained abdominal obesity at age 50, increases colon cancer risk in both men and women. These data underline the importance of weight management and metabolic health maintenance in early adult life years for colon cancer prevention. (C) 2013 Elsevier Ltd. All rights reserved.

引用

页码：3526 / 3536

页数：11

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