Synthesis of optically active bisdifluorocyclopropanes through a chemo-enzymatic reaction strategy

被引：25

作者：

Mitsukura, K ^{[1
]}

Korekiyo, S ^{[1
]}

Itoh, T ^{[1
]}

机构：

[1] Okayama Univ, Fac Educ, Dept Chem, Okayama 7008530, Japan

来源：

TETRAHEDRON LETTERS | 1999年 / 40卷 / 31期

关键词：

D O I：

10.1016/S0040-4039(99)01088-6

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

The first synthesis of bisdifluorocyclopropane derivatives has been accomplished via a chemo-enzymatic reaction strategy; (E)- or (Z)-3-tributylstannyl-2-propenols were prepared and their conversion led to the (trans, trans)- and(cis, cis) -bisdifluorocyclopropanes. The subsequent lipase-catalyzed reaction efficiently afforded optically active (trans, trans)2,2,5,5-tetrafluoro-1,6-bis(hydroxymethyl)bicyclopropane. (C) 1999 Published by Elsevier Science Ltd. All rights reserved.

引用

页码：5739 / 5742

页数：4

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