RNA interference in the nucleus: roles for small RNAs in transcription, epigenetics and beyond

被引：686

作者：

Castel, Stephane E. ^{[1
]}

Martienssen, Robert A. ^{[1
,2
]}

机构：

[1] Cold Spring Harbor Lab, Watson Sch Biol Sci, Cold Spring Harbor, NY 11724 USA

[2] Gordon & Betty Moore Fdn, Howard Hughes Med Inst, Palo Alto, CA USA

来源：

NATURE REVIEWS GENETICS | 2013年 / 14卷 / 02期

基金：

美国国家科学基金会; 加拿大自然科学与工程研究理事会;

关键词：

PROGRAMMED DNA ELIMINATION; ENDOGENOUS SIRNA PATHWAY; DE-NOVO METHYLATION; NONCODING RNA; POLYMERASE-II; HISTONE H3; TRANSPOSABLE ELEMENTS; GENE-EXPRESSION; HETEROCHROMATIN; ARABIDOPSIS;

D O I：

10.1038/nrg3355

中图分类号：

Q3 [遗传学];

学科分类号：

071007 ; 090102 ;

摘要：

A growing number of functions are emerging for RNA interference (RNAi) in the nucleus, in addition to well-characterized roles in post-transcriptional gene silencing in the cytoplasm. Epigenetic modifications directed by small RNAs have been shown to cause transcriptional repression in plants, fungi and animals. Additionally, increasing evidence indicates that RNAi regulates transcription through interaction with transcriptional machinery. Nuclear small RNAs include small interfering RNAs (siRNAs) and PIWI-interacting RNAs (piRNAs) and are implicated in nuclear processes such as transposon regulation, heterochromatin formation, developmental gene regulation and genome stability.

引用

页码：100 / 112

页数：13

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