RNA interference in the nucleus: roles for small RNAs in transcription, epigenetics and beyond

被引：700

作者：

Castel, Stephane E. ^{[1
]}

Martienssen, Robert A. ^{[1
,2
]}

机构：

[1] Cold Spring Harbor Lab, Watson Sch Biol Sci, Cold Spring Harbor, NY 11724 USA

[2] Gordon & Betty Moore Fdn, Howard Hughes Med Inst, Palo Alto, CA USA

来源：

NATURE REVIEWS GENETICS | 2013年 / 14卷 / 02期

基金：

美国国家科学基金会; 加拿大自然科学与工程研究理事会;

关键词：

PROGRAMMED DNA ELIMINATION; ENDOGENOUS SIRNA PATHWAY; DE-NOVO METHYLATION; NONCODING RNA; POLYMERASE-II; HISTONE H3; TRANSPOSABLE ELEMENTS; GENE-EXPRESSION; HETEROCHROMATIN; ARABIDOPSIS;

D O I：

10.1038/nrg3355

中图分类号：

Q3 [遗传学];

学科分类号：

071007 ; 090102 ;

摘要：

A growing number of functions are emerging for RNA interference (RNAi) in the nucleus, in addition to well-characterized roles in post-transcriptional gene silencing in the cytoplasm. Epigenetic modifications directed by small RNAs have been shown to cause transcriptional repression in plants, fungi and animals. Additionally, increasing evidence indicates that RNAi regulates transcription through interaction with transcriptional machinery. Nuclear small RNAs include small interfering RNAs (siRNAs) and PIWI-interacting RNAs (piRNAs) and are implicated in nuclear processes such as transposon regulation, heterochromatin formation, developmental gene regulation and genome stability.

引用

页码：100 / 112

页数：13

共 127 条

[61] Genome-wide profiling and analysis of Arabidopsis siRNAs [J].

Kasschau, Kristin D. ;

Fahlgren, Noah ;

Chapman, Elisabeth J. ;

Sullivan, Christopher M. ;

Cumbie, Jason S. ;

Givan, Scott A. ;

Carrington, James C. .

PLOS BIOLOGY, 2007, 5 (03) :479-493

[62] RNA polymerase II is required for RNAi-dependent heterochromatin assembly [J].

Kato, H ;

Goto, DB ;

Martienssen, RA ;

Urano, T ;

Furukawa, K ;

Murakami, Y .

SCIENCE, 2005, 309 (5733) :467-469

[63] Interaction of RNA polymerase II and the small RNA machinery affects heterochromatic silencing in Drosophila [J].

Kavi, Harsh H. ;

Birchler, James A. .

EPIGENETICS & CHROMATIN, 2009, 2

[64] Transcriptional Control of Gene Expression by MicroRNAs [J].

Khraiwesh, Basel ;

Arif, M. Asif ;

Seumel, Gotelinde I. ;

Ossowski, Stephan ;

Weigel, Detlef ;

Reski, Ralf ;

Frank, Wolfgang .

CELL, 2010, 140 (01) :111-122

[65] Distinct Functions for the Drosophila piRNA Pathway in Genome Maintenance and Telomere Protection [J].

Khurana, Jaspreet S. ;

Xu, Jia ;

Weng, Zhiping ;

Theurkauf, William E. .

PLOS GENETICS, 2010, 6 (12) :1-8

[66] Argonaute-1 directs siRNA-mediated transcriptional gene silencing in human cells [J].

Kim, Daniel H. ;

Villeneuve, Louisa M. ;

Morris, Kevin V. ;

Rossi, John J. .

NATURE STRUCTURAL & MOLECULAR BIOLOGY, 2006, 13 (09) :793-797

[67] Biogenesis of small RNAs in animals [J].

Kim, V. Narry ;

Han, Jinju ;

Siomi, Mikiko C. .

NATURE REVIEWS MOLECULAR CELL BIOLOGY, 2009, 10 (02) :126-139

[68] The Drosophila HP1 Homolog Rhino Is Required for Transposon Silencing and piRNA Production by Dual-Strand Clusters [J].

Klattenhoff, Carla ;

Xi, Hualin ;

Li, Chengjian ;

Lee, Soohyun ;

Xu, Jia ;

Khurana, Jaspreet S. ;

Zhang, Fan ;

Schultz, Nadine ;

Koppetsch, Birgit S. ;

Nowosielska, Anetta ;

Seitz, Herve ;

Zamore, Phillip D. ;

Weng, Zhiping ;

Theurkauf, William E. .

CELL, 2009, 138 (06) :1137-1149

[69] Separation of stem cell maintenance and transposon silencing functions of Piwi protein [J].

Klenov, Mikhail S. ;

Sokolova, Olesya A. ;

Yakushev, Evgeny Y. ;

Stolyarenko, Anastasia D. ;

Mikhaleva, Elena A. ;

Lavrov, Sergey A. ;

Gvozdev, Vladimir A. .

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 2011, 108 (46) :18760-18765

[70] RNA interference guides histone modification during the S phase of chromosomal replication [J].

Kloc, Anna ;

Zaratiegui, Mikel ;

Nora, Elphege ;

Martienssen, Rob .

CURRENT BIOLOGY, 2008, 18 (07) :490-495

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