Hair cell regeneration

被引：62

作者：

Edge, Albert S. B. ^{[1
,2
,3
]}

Chen, Zheng-Yi ^{[1
,2
,3
]}

机构：

[1] Harvard Univ, Sch Med, Dept Otol & Laryngol, Boston, MA 02115 USA

[2] Massachusetts Eye & Ear Infirm, Eaton Peabody Lab, Tiliotson Unit Cell Biol, Boston, MA 02114 USA

[3] Harvard & MIT, Div Hlth Sci & Technol, Program Speech & Hearing Biosci & Technol, Cambridge, MA 02139 USA

来源：

CURRENT OPINION IN NEUROBIOLOGY | 2008年 / 18卷 / 04期

关键词：

D O I：

10.1016/j.conb.2008.10.001

中图分类号：

Q189 [神经科学];

学科分类号：

071006 ;

摘要：

The mammalian inner ear largely lacks the capacity to regenerate hair cells, the sensory cells required for hearing and balance. Recent studies in both lower vertebrates and mammals have uncovered genes and pathways important in hair cell development and have suggested ways that the sensory epithelia could be manipulated to achieve hair cell regeneration. These approaches include the use of inner ear stem cells, transdifferentiation of nonsensory cells, and induction of a proliferative response in the cells that can become hair cells.

引用

页码：377 / 382

页数：6

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